Cognitive Dysfunctions in Middle-Aged Type 2 Diabetic Patients and Neuroimaging Correlations: A Cross-Sectional Study
| Autor: | Pedro Gonzalez-Alegre, Marcelo L. Berthier, Ricardo E. Jorge, Alejandro Nabrozidis, Natalia García-Casares, Pedro González-Santos, José Rioja, María José Ariza, Antonio Gutiérrez, Laura Acion, Juan Garcia-Arnes |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Wechsler Memory Scale medicine.medical_specialty Neuropsychological Tests Audiology Developmental psychology Fluorodeoxyglucose F18 Image Processing Computer-Assisted medicine Humans Prefrontal cortex Aged Framingham Risk Score Recall General Neuroscience Neuropsychology Brain General Medicine Middle Aged Executive functions Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies Glucose Diabetes Mellitus Type 2 Positron-Emission Tomography Female Radiopharmaceuticals Geriatrics and Gerontology Verbal memory Cognition Disorders Psychology Stroop effect |
| Zdroj: | Journal of Alzheimer's Disease. 42:1337-1346 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-140702 |
| Popis: | Background/Objective: The aim was to assess the neuropsychological performance of a group of middle-aged patients with well-controlled type 2 diabetes mellitus (T2DM) and to examine whether the neuropsychological deficits correlate with structural and functional brain alterations. Methods: We compared 25 subjects with T2DM aged 45–65 years with 25 control participants matched for age, gender, and educational level. The neuropsychological battery was designed to examine executive functions, attention, information processing speed, and verbal memory. Severity of depression was assessed using the Hamilton Depression Rating Scale and cardiovascular risk factors were assessed using the Framingham Cardiovascular Risk Profile Score. The presence of at least one APOE4 allele was determined. Reduced gray matter density was analyzed using voxel-based morphometry and brain glucose metabolic changes were assessed by 18 FDG-PET. Results: T2DM subjects had significantly lower scores than subjects without T2DM in the Trail-making Test B (p < 0.004), Color-Word Stroop test (p < 0.005), Semantic Fluency (p < 0.006), Digit-Symbol modalities test (p < 0.02), Text Recall from the Wechsler Memory Scale (p < 0.0001), Rey-Osterrieth Complex Figure-copy (p < 0.004), and delayed reproduction (p < 0.03). Worse executive functions and memory functioning correlated predominantly with less gray matter density and reduced glucose metabolism in the orbital and prefrontal cortex, temporal (middle gyrus, parahippocampus and uncus), and cerebellum regions (p < 0.001). Conclusions: T2DM subjects presented cognitive dysfunctions compared with controls. Clinical-neuroimaging correlations corresponded to brain changes (reduced gray matter density and glucose metabolism) mainly in fronto-temporal areas. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|