Synthesis and in vitro antibacterial activity of gemifloxacin derivatives containing a substituted benzyloxime moiety
| Autor: | Jing Zhao, Su-Jie Li, Lian-Shun Feng, Xuefu You, Huiyuan Guo, Jue Cao, Kai Lv, Shuo Wang, Mingliang Liu |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Bacteria Gemifloxacin Chemistry Stereochemistry Organic Chemistry General Medicine Chemistry Techniques Synthetic Microbial Sensitivity Tests In vitro Anti-Bacterial Agents Levofloxacin Moxifloxacin Drug Discovery Lipophilicity Oximes medicine Moiety Potency Naphthyridines Antibacterial activity Hydrophobic and Hydrophilic Interactions medicine.drug Fluoroquinolones |
| Zdroj: | European journal of medicinal chemistry. 55 |
| ISSN: | 1768-3254 |
| Popis: | A series of novel gemifloxacin (GMFX) derivatives containing a substituted benzyloxime moiety with remarkable improvement in lipophilicity were synthesized. The target compounds evaluated for their in vitro antibacterial activity against representative strains. Our results reveal that most of the target compounds have considerable potency against all of the tested gram-positive strains including MRSA and MRSE (MIC |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect