Metabolic and Structural Skeletal Muscle Health in Systemic Lupus Erythematosus-Related Fatigue: A Multimodal Magnetic Resonance Imaging Study
| Autor: | Gordon D. Waiter, Paula Dospinescu, Andrew Schrepf, Jiabao He, Gayle Hutcheon, Lars Erwig, Stuart R. Gray, Kwokshing Chan, Karen Forrest Keenan, Nicholas Senn, Neil Basu, Sai Man Cheung |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy Fat quantification Multimodal Imaging 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Rheumatology Internal medicine medicine Humans Lupus Erythematosus Systemic Muscle Strength skin and connective tissue diseases Muscle Skeletal health care economics and organizations Fatigue Peripheral muscle 030203 arthritis & rheumatology Multimodal imaging Lupus erythematosus Systemic lupus erythematosus medicine.diagnostic_test business.industry Skeletal muscle Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Diffusion Tensor Imaging Case-Control Studies Female business |
| Zdroj: | Arthritis careresearchReferences. 71(12) |
| ISSN: | 2151-4658 |
| Popis: | To investigate the potential structural and metabolic role of skeletal muscle in systemic lupus erythematosus (SLE)-related fatigue.A case-control, multimodal magnetic resonance imaging (MRI) study was conducted. Cases were patients with inactive SLE who reported chronic fatigue. Controls were age- and sex-matched healthy members of the general population. Patients were clinically characterized and then underwent a 3T whole-body MRI scan. Resting and dynamicOf the 37 recruits (mean age 43.8 years, 89.2% female), cases (n = 19) reported higher levels of physical fatigue, pain, depression, and sleep disturbance compared to the control group (P0.0001). PCr was greater (P = 0.045) among cases (mean ± SD 33.0 ± 9.0 seconds) compared to controls (mean ± SD 27.1 ± 6.6 seconds). No microstructural group differences were observed. Within cases, physical fatigue did not correlate with PCr (r = -0.28, P = 0.25).We report preliminary data demonstrating greater skeletal muscle mitochondrial dysfunction among fatigued patients with SLE compared to healthy controls. |
| Databáze: | OpenAIRE |
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