Prevalence of opportunistic invasive aspergillosis in COVID‐19 patients with severe pneumonia
| Autor: | Estefanía Llopis-Pastor, Marta Hernández-Hernández, Javier Carrillo, Susana Frases, Mercedes García-Salmones, Glauber R. de S. Araújo, Inés Escribano, Laura Rey, Nestor Rodriguez Melean, Celia Zamarro, Gonzalo Segrelles-Calvo, Esther Antón |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty lung disease 030106 microbiology Dermatology Opportunistic Infections medicine.disease_cause Aspergillosis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine COVID‐19 Pandemic medicine Prevalence Humans Prospective Studies Risk factor Intensive care medicine Coronavirus Aged Invasive Pulmonary Aspergillosis invasive aspergillosis business.industry SARS-CoV-2 COVID-19 General Medicine Original Articles Middle Aged medicine.disease Hospitalization Pneumonia opportunistic mycosis Infectious Diseases Aspergillus Spain Observational study Original Article Female Viral disease business Intermediate Care Facilities Cohort study |
| Zdroj: | Mycoses |
| ISSN: | 1439-0507 0933-7407 |
| Popis: | Background As the global coronavirus pandemic (COVID-19) spreads across the world, new clinical challenges emerge in the hospital landscape. Among these challenges, the increased risk of coinfections is a major threat to the patients. Although still in a low number, due to the short time of the pandemic, studies that identified a significant number of hospitalised patients with COVID-19 who developed secondary fungal infections that led to serious complications and even death have been published. Objectives In this scenario, we aim to determine the prevalence of invasive fungal infections (IFIs) and describe possible associated risk factors in patients admitted due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Patients/methods We designed an open prospective observational study at the Rey Juan Carlos University Hospital (Mostoles, Spain), during the period from February 1 to April 30, 2020. Results In this article, we reported seven patients with COVID-19-associated pulmonary aspergillosis (CAPA) who had a poor prognosis. Severely ill patients represent a high-risk group; therefore, we must actively investigate the possibility of aspergillosis in all of these patients. Larger cohort studies are needed to unravel the role of COVID-19 immunosuppressive therapy as a risk factor for aspergillosis. Conclusions As the pandemic continues to spread across the world, further reports are needed to assess the frequency of emergent and highly resistant reemergent fungal infections during severe COVID-19. These coinfections are leading a significant number of patients with COVID-19 to death due to complications following the primary viral disease. |
| Databáze: | OpenAIRE |
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