Relationship of angiotensin-converting enzyme gene polymorphism with nephropathy associated with Type 2 diabetes mellitus in Asian Indians
| Autor: | Qurratulain Hasan, Kiran Kumar Vattam, Somashekhar Mubigonda, Ravindra Varma Alluri, Kamal Kiran Mukkavali, Jandayala C. Shastry, Kavitha Eppa, Sarbeshwar Saharia, Sireesha Movva, Sreelatha Komandur |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Asia Genotype Endocrinology Diabetes and Metabolism Population India Peptidyl-Dipeptidase A Nephropathy Diabetic nephropathy Endocrinology Internal medicine Internal Medicine Humans Medicine Diabetic Nephropathies Genetic Predisposition to Disease education Alleles education.field_of_study Polymorphism Genetic biology business.industry Type 2 Diabetes Mellitus Angiotensin-converting enzyme Middle Aged medicine.disease Angiotensin II Diabetes Mellitus Type 2 biology.protein Female Gene polymorphism business |
| Zdroj: | Journal of Diabetes and its Complications. 21:237-241 |
| ISSN: | 1056-8727 |
| Popis: | Diabetic nephropathy (DN) has become the leading cause of end-stage renal disease, but the pathogenesis of this condition is not exactly understood. Several studies from different parts of the world have examined angiotensin-converting enzyme (ACE) gene polymorphism as a candidate for DN. Two studies yielding controversial results have been reported from India. To rule out this discrepancy, we carried out a hospital-based study on a cohort from our population to determine whether ACE gene polymorphism is associated with DN.ACE gene polymorphism was analyzed by polymerase chain reaction in 460 individuals consisting of 174 cases of DN, 175 cases of Type 2 diabetes mellitus (DM), and 111 controls. The DN cases included in the study were Type 2 DM cases with serum creatinine1.5 mg/dl and serum albumin30 mg/dl in a 24-h urine sample.ACE insertion/deletion genotyping analysis showed DD genotype in 22.75% of DN cases, 15.42% of Type 2 DM cases, and 21.62% of controls. Chi-square test between the DN group and the control group did not show a significant difference in D allele. However, the difference was significant at P.05 between the DN group and the DM group. The odds ratio was 2.0953 (95% confidence interval=1.35-3.2522), indicating a significant association of DD genotype and D allele with DN.Our data enable us to conclude that Asian Indians with D allele and Type 2 DM are at greater risk for developing DN. |
| Databáze: | OpenAIRE |
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