Aqueous Stem Bark Extract of Stereospermum Kunthianum (Cham, Sandrine Petit) Protects Against Generalized Seizures in Pentylenetetrazole and Electro-Convulsive Models in Rodents
| Autor: | I. O. Otokiti, F. P. Ching, E. K. I. Omogbai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_treatment
ved/biology.organism_classification_rank.species Bignoniaceae Nigeria Pharmacology behavioral disciplines and activities Mice Seizures Drug Discovery Medicine Animals Rats Wistar Medicinal plants Stem bark Electroshock biology Traditional medicine business.industry ved/biology Stereospermum kunthianum Anticonvulsant activity maximal Electroshock pentylenetetra-zole Plant Extracts biology.organism_classification Stereospermum kunthianum Rats Maximal electroshock Ethosuximide Anticonvulsant Complementary and alternative medicine visual_art visual_art.visual_art_medium Plant Bark Pentylenetetrazole Bark Anticonvulsants business medicine.drug Research Paper Phytotherapy |
| Zdroj: | African Journal of Traditional, Complementary and Alternative Medicines; Vol 6, No 4 (2009) |
| ISSN: | 0189-6016 |
| Popis: | Stereospermum kunthianum, Cham Sandrine Petit (Bignoniaceae) known in English as pink jacaranda is used in traditional medicine to treat an array of ailments including febrile convulsions in infants and young children by the rural dwellers in Nigeria. This study examined the anticonvulsant activity of its aqueous stem bark extract (100 – 400mg/kg) against maximal electroshock and pentylenetetrazole-induced seizures in rodents. Phenobarbitone and ethosuximide were used as reference anticonvulsant drugs for comparison. Stereospermum kunthianum extract (200 – 400mg/kg, i.p.) remarkably protected (76.9% and 84.6 % respectively) the rats against electroshock-induced seizures. However, the extract (200- 400mg/kg) when administered orally showed a comparatively less effect (33.3% and 55.6% respectively) to the intraperitoneally administered extract in the maximal electroshock test. The extract (100–400mg/kg, i.p.) significantly delayed (p |
| Databáze: | OpenAIRE |
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