Association Between Liver Fat and Bone Density is Confounded by General and Visceral Adiposity in a Community‐Based Cohort

Autor: Elizabeth J. Samelson, Laura E. Dichtel, Na Wang, Tracey G. Simon, Raymond T. Chung, Kathleen E. Corey, Douglas P. Kiel, Michelle T. Long, Belinda T Li
Rok vydání: 2021
Předmět:
Adult
Male
medicine.medical_specialty
Bone density
Cross-sectional study
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
030209 endocrinology & metabolism
Intra-Abdominal Fat
Gastroenterology
Article
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Endocrinology
Framingham Heart Study
Bone Density
Non-alcoholic Fatty Liver Disease
Residence Characteristics
Internal medicine
Nonalcoholic fatty liver disease
medicine
Humans
Obesity
030212 general & internal medicine
Adiposity
Bone mineral
Nutrition and Dietetics
business.industry
Confounding
nutritional and metabolic diseases
Confounding Factors
Epidemiologic
Middle Aged
medicine.disease
Spine
Cross-Sectional Studies
Adipose Tissue
Liver
Obesity
Abdominal
Cohort
Osteoporosis
Female
Tomography
X-Ray Computed
business
Body mass index
Zdroj: Obesity (Silver Spring)
ISSN: 1930-739X
1930-7381
Popis: Objective Nonalcoholic fatty liver disease (NAFLD) is associated with low bone mineral density (BMD); however, it is not known whether early-stage NAFLD may be associated with BMD after accounting for BMI or visceral adipose tissue (VAT). Methods This was a cross-sectional study of 3,462 Framingham Heart Study participants who underwent computed tomographic measurement of liver fat, VAT volume, volumetric spine BMD, vertebral cross-sectional area (CSA), and vertebral compressive strength. This study excluded heavy alcohol consumers. Multivariable linear regression models were used to assess the association between NAFLD and volumetric BMD, CSA, and vertebral compressive strength after accounting for covariates, including BMI or VAT. Results A total of 2,253 participants (mean age, 51.2 [SD 10.7] years; 51.1% women) were included. In multivariable-adjusted models, positive associations between NAFLD and integral BMD, trabecular BMD, and vertebral compressive strength were observed. However, results were attenuated and no longer significant after additionally adjusting for BMI or VAT. NAFLD was observed to be weakly associated with a lower vertebral CSA in adjusted models. Conclusions In a community-based cohort, the associations between NAFLD and BMD and vertebral strength were confounded by BMI and VAT. However, NAFLD was associated with a reduced vertebral CSA in adjusted models.
Databáze: OpenAIRE
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