Licensing delineates helper and effector NK cell subsets during viral infection
| Autor: | G. Raymond Lochhead, Dan L. Longo, Jeffrey M. Venstrom, Cordelia Dunai, William J. Murphy, Lam T. Khuat, Nicole Baumgarth, Claire Pomeroy, Juan Du, Ethan G. Aguilar, Bruce R. Blazar, Anthony E. Zamora, Can M. Sungur |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
T cell Immunology Biology Vaccine Related 03 medical and health sciences Immune system Antigen Biodefense medicine 2.1 Biological and endogenous factors Aetiology Receptor Inflammation Effector Prevention Inflammatory and immune system General Medicine Dendritic cell Acquired immune system Emerging Infectious Diseases Infectious Diseases 030104 developmental biology medicine.anatomical_structure Infection CD8 Research Article |
| Zdroj: | JCI insight, vol 2, iss 10 |
| ISSN: | 2379-3708 |
| Popis: | Natural killer (NK) cells can be divided into phenotypic subsets based on expression of receptors that bind self-MHC-I molecules, a concept termed licensing or education. Here we show NK cell subsets with different migratory, effector, and immunoregulatory functions in dendritic cell and antigen (ag)-specific CD8+ T cell responses during influenza and murine cytomegalovirus infections. Shortly after infection, unlicensed NK cells localized in draining lymph nodes and produced GM-CSF, which correlated with the expansion and activation of dendritic cells, and resulted in greater and sustained ag-specific T cell responses. In contrast, licensed NK cells preferentially migrated to infected tissues and produced IFN-γ. Importantly, human NK cell subsets exhibited similar phenotypic characteristics. Collectively, our studies demonstrate a critical demarcation between the functions of licensed and unlicensed NK cell subsets, with the former functioning as the classical effector subset and the latter as the stimulator of adaptive immunity helping to prime immune responses. |
| Databáze: | OpenAIRE |
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