| Autor: |
Xue-Zhi Wu, Hong-Min Wang, Guo-Xing Li, Han-Song Zheng |
| Jazyk: |
angličtina |
| Předmět: |
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| Zdroj: |
Asian Pacific Journal of Tropical Medicine. (2):153-156 |
| ISSN: |
1995-7645 |
| DOI: |
10.1016/S1995-7645(14)60307-2 |
| Popis: |
ObjectiveTo study the protective effect of resveratrol on lens epithelial cell apoptosis in diabetic cataract rat.MethodsA total of 84 Wistar rats were divided into 4 groups: 12 in Group A (control group), 24 in Group B (diabetic cataract group), 24 in Group C (therapeutic–dose of resveratrol group) and 24 in Group D (low–dose of resveratrol group). Rats in Group B–D were given with 60 mg/kg streptozotocin through intraperitoneal injection. Rats in Group C were given with 100 mg/kg resveratrol and rats in Group D were given with 20 mg/kg resveratrol. The caspase–3 expression levels and apoptosis ratios of LEC among each group were observed; the degrees of lens opacity in Group B–D after 12 weeks were compared.ResultsThere were significant differences in caspase–3 expression levels, apoptosis ratios of LEC among groups at 4 w, 8 w and 12 w (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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