Synthesis of Oxygen-Containing Heterocyclic Compounds by Iron-Catalyzed Alkylative Cyclization of Unsaturated Carboxylic Acids and Alcohols
| Autor: | Masayuki Iwasaki, Yasushi Nishihara, Yasuki Kazao, Takumi Ishida |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Chemistry Alkene Iron catalyzed Organic Chemistry Intramolecular cyclization Substrate (chemistry) chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Oxygen 0104 chemical sciences Nucleophile Organic chemistry Physical and Theoretical Chemistry Alkyl |
| Zdroj: | Organic Letters. 22:7343-7347 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | Iron-catalyzed alkylative cyclization of alkenes bearing oxygen nucleophiles with secondary and tertiary alkyl bromides through carbon-carbon and carbon-oxygen bond formations has been developed. A broad substrate scope is an attractive feature of this synthetic method, providing a variety of potentially bioactive five- and six-membered oxygen-containing heterocycles. The reaction pathway is proposed to involve a radical addition of the in situ-formed alkyl radical to an alkene followed by carbon-oxygen bond-forming intramolecular cyclization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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