Preclinical promise of becaplermin (rhPDGF-BB) in wound healing
| Autor: | Edmund K. LeGrand |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Platelet-derived growth factor
Swine medicine.medical_treatment Guinea Pigs Becaplermin Bioinformatics Mice chemistry.chemical_compound Skin Ulcer medicine Animals Humans Platelet-Derived Growth Factor Wound Healing business.industry Growth factor Anticoagulants Granulation tissue Proto-Oncogene Proteins c-sis General Medicine Skin ulcer Recombinant Proteins Rats Clinical trial Disease Models Animal medicine.anatomical_structure chemistry Immunology Surgery Animal studies medicine.symptom business Wound healing medicine.drug |
| Zdroj: | The American Journal of Surgery. 176:48S-54S |
| ISSN: | 0002-9610 |
| Popis: | Advances in molecular biology have made possible the production of highly purified recombinant human proteins, and recombinant human growth factors have emerged as potential therapeutic wound healing agents. Becaplermin (recombinant human platelet-derived growth factor-BB [rhPDGF-BB]) quickly emerged as one of the leading candidates for clinical trials. Before the expected therapeutic potential of rhPDGF-BB and other growth factors could be realized, a number of concerns had to be addressed (eg, would growth factors show effects in normal animals, what parameters of wound healing would be affected, and would quality of healed wounds be normal?). In animal models, rhPDGF-BB demonstrated wound healing activity, predominantly by enhancing the formation of granulation tissue, but it was not known whether this effect on granulation tissue would translate into enhanced healing of chronic skin ulcers in humans. The objective of this article is to review how the study of rhPDGF-BB in animal wound healing models has assisted in addressing the potential clinical utility of rhPDGF-BB. Results of animal studies are summarized, and the advantages and limitations of the animal models are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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