Autor: |
Laura Belanger, Limei Zhang, Maria L. Webb, Yajing Rong, Quynhchi Pham, Steven G. Kultgen, Susan M. Parlato, Andrew Laird Roughton, Tiffany L. Walker, Yan Xu, Michael Ohlmeyer, Bing Hu, Koc-Kan Ho, Anthony E. Klon, David A. Dunn, Darcey Black, Peter C. Ray, James R. Beasley, Jane Wright, Jui-Hsiang Chan, Kai Xu |
Rok vydání: |
2009 |
Předmět: |
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Zdroj: |
Bioorganic & Medicinal Chemistry Letters. 19:6027-6031 |
ISSN: |
0960-894X |
Popis: |
The profile of a series of triazine and pyrimidine based ROCK inhibitors is described. An initial binding mode was established based on a homology model and the proposed interactions are consistent with the observed SAR. Compounds from the series are potent in a cell migration assay and possess a favorable kinase selectivity. In vivo activity was demonstrated for compound 1A in a spontaneous hypertensive rat model. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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