Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID
| Autor: | Antonova, Simona V, Boeren, Jeffrey, Timmers, H T Marc, Snel, Berend, Sub Bioinformatics, Theoretical Biology and Bioinformatics |
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| Přispěvatelé: | Developmental Biology, Sub Bioinformatics, Theoretical Biology and Bioinformatics |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Evolution
Transcription Factor TFIID/genetics genetic processes information science macromolecular substances Biology Epigenesis Genetic Evolution Molecular 03 medical and health sciences 0302 clinical medicine Genetic Transcription (biology) Genetics Transcriptional regulation Special Section: Perspective Phylogeny 030304 developmental biology 0303 health sciences General transcription factor fungi Eukaryota Molecular Biodiversity Chromatin Cell biology Eukaryota/classification TAF1 Gene Expression Regulation TAF4 030220 oncology & carcinogenesis TAF2 health occupations Transcription Factor TFIID Transcription factor II D Developmental Biology Epigenesis |
| Zdroj: | Genes and Development, 33(15-16), 888. Cold Spring Harbor Laboratory Press Genes & Development, 33(15-16), 888-902. Cold Spring Harbor Laboratory Press |
| ISSN: | 0890-9369 |
| Popis: | The basal transcription factor TFIID is central for RNA polymerase II-dependent transcription. Human TFIID is endowed with chromatin reader and DNA-binding domains and protein interaction surfaces. Fourteen TFIID TATA-binding protein (TBP)-associated factor (TAF) subunits assemble into the holocomplex, which shares subunits with the Spt–Ada–Gcn5–acetyltransferase (SAGA) coactivator. Here, we discuss the structural and functional evolution of TFIID and its divergence from SAGA. Our orthologous tree and domain analyses reveal dynamic gains and losses of epigenetic readers, plant-specific functions of TAF1 and TAF4, the HEAT2-like repeat in TAF2, and, importantly, the pre-LECA origin of TFIID and SAGA. TFIID evolution exemplifies the dynamic plasticity in transcription complexes in the eukaryotic lineage. |
| Databáze: | OpenAIRE |
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