The complex interplay between gastrointestinal and psychiatric symptoms in irritable bowel syndrome: A longitudinal assessment
| Autor: | Massimo Bellini, Dario Gambaccini, Cristina Stasi, Stefano Salvadori, C Nisita, Nicola de Bortoli, Santino Marchi, B. Fani, Lorenzo Bertani, Liliana Dell'Osso, Andrea Pancetti, S. Cortopassi, Corrado Blandizzi, Anna Caserta |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Severity of Illness Index Irritable Bowel Syndrome 03 medical and health sciences Young Adult 0302 clinical medicine Quality of life Internal medicine Medicine Humans Longitudinal Studies Prospective Studies Functional disorders Gastric motility and sensation Motility and nerve-gut interactions/brain-gut axis regulation Hepatology Gastroenterology Major depressive episode Psychiatry Irritable bowel syndrome Aged business.industry Panic disorder Mental Disorders Middle Aged medicine.disease Paroxetine Diarrhea Treatment Outcome 030220 oncology & carcinogenesis Quality of Life 030211 gastroenterology & hepatology Female medicine.symptom business Psychopathology medicine.drug |
| Zdroj: | Journal of gastroenterology and hepatology. 34(4) |
| ISSN: | 1440-1746 |
| Popis: | AIMS The aims of this study were to better define the relationship between irritable bowel syndrome (IBS) and psychiatric disorders and to examine the efficacy of paroxetine in the treatment of IBS patients. METHODS One hundred fifty subjects with diagnosis of IBS (Roma III criteria) and relative sub-classification (constipated, diarrhea, and mixed) were assessed for psychopathological features and gastrointestinal symptoms using IBS Symptom Severity Score and were consecutively enrolled. Fifty patients assumed paroxetine for 16 weeks and were longitudinally evaluated. RESULTS The entire sample had a moderate/severe gastrointestinal symptomatology (IBS-SSS 285.1 ± 98.6). The IBS subtypes were diarrhea (47.3%), constipated (32%), and mixed (20.7%). Panic disorder was found in 17.4% and major depressive episode in 14.7%. More than 50% of the patients showed "psychopathological features." This group showed more severe gastrointestinal symptoms and worse quality of life than the group without any psychiatric comorbidity (44%). Psychiatric patients also showed a significant impairment of physical state, subjective feeling of well-being, and leisure activities when compared with no psychiatric patients. When the IBS-SSS > 300 group was subgrouped in psychiatric (67.2%) and no psychiatric (32.8%), we found significant differences in all clinician-administered and self-reported scales with more severe psychopathological features in psychiatric group (P |
| Databáze: | OpenAIRE |
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