Estimated glomerular filtration rate equations in people of self-reported black ethnicity in the United Kingdom: Inappropriate adjustment for ethnicity may lead to reduced access to care

Autor: Kate Bramham, Neil Heraghty, Henry Kibble, Rouvick M Gama, Hugh Cairns, Kieran Palmer, Kathryn Griffiths, Claire C. Sharpe, Adrien Michael Peters, Royce P Vincent, Amanda Clery
Rok vydání: 2021
Předmět:
Male
Databases
Factual
Epidemiology
Physiology
Ethnic group
urologic and male genital diseases
Biochemistry
chemistry.chemical_compound
Chronic Kidney Disease
Medicine and Health Sciences
Odds Ratio
Ethnicities
Medicine
African American people
Lead (electronics)
Multidisciplinary
Middle Aged
female genital diseases and pregnancy complications
Nephrology
Creatinine
Cohort
Female
Algorithms
Research Article
Glomerular Filtration Rate
Adult
Science
Black People
Renal function
White People
Ethnic Epidemiology
Albumins
Renal Diseases
Humans
Renal Insufficiency
Chronic
Aged
African People
Renal Physiology
business.industry
Biology and Life Sciences
Proteins
medicine.disease
United Kingdom
Cross-Sectional Studies
chemistry
People and Places
Linear Models
Population Groupings
Self Report
business
Biomarkers
Demography
Kidney disease
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 8, p e0255869 (2021)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0255869
Popis: Assessment in African populations suggest adjustment for ethnicity in estimated glomerular filtration rate (eGFR) equations derived from African Americans lead to overestimation of GFR and failure to determine severity in chronic kidney disease (CKD). However, studies in African Europeans are limited. We aimed to assess accuracy of eGFR equations, with and without ethnicity adjustment compared with measured GFR in people of Black ethnicity in the United Kingdom. Performance of MDRD, CKD-EPI (with and without ethnicity adjustment), Full Age Spectrum (FAS), revised Lund Malmö (LM Revised), and European Kidney Function Consortium (EKFC) eGFR equations were assessed compared to 51Cr-EDTA GFR studies extracted from hospital databases. Participants with albumin 51Cr-EDTA studies were included (Mean age-53.7yrs; 43.6% female; 14.1% Black ethnicity). Compared to White participants, eGFR-MDRD and eGFR-CKD-EPI equations in Black participants significantly overestimated GFR (bias 20.3 and 19.7 ml/min/1.73m2 respectively, p2 for eGFR-MDRD and eGFR-CKD-EPI respectively, p2 respectively). 30%-accuracy was superior for GFR≥60ml/min/1.73m2 compared to 2 using eGFR-CKD-EPI equation for both White and Black participants (p
Databáze: OpenAIRE
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