Serological survey and risk factors associated with Toxoplasma gondii infection among HIV-infected pregnant women attending Abuja Tertiary Hospital, Nigeria
| Autor: | AY Isah, Thairu Yunusa, Richard Offiong, Maryam Muhammad Zakari, Idris Nasir Abdullahi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cellular immunity HIV Infections Miscarriage Serology 0302 clinical medicine Pregnancy Risk Factors Seroepidemiologic Studies Surveys and Questionnaires HIV Seropositivity Original Research biology Coinfection Obstetrics Gestational age Prenatal Care General Medicine Middle Aged Female Toxoplasma Toxoplasmosis Adult medicine.medical_specialty 030231 tropical medicine 030106 microbiology Nigeria Enzyme-Linked Immunosorbent Assay cellular immunity sero-survey Young Adult 03 medical and health sciences parasitic diseases medicine Humans Seroprevalence HIV coinfection business.industry Toxoplasma gondii medicine.disease biology.organism_classification Cross-Sectional Studies Immunoglobulin M congenital anomaly Immunoglobulin G Pregnancy Complications Parasitic Pregnant Women business |
| Zdroj: | Malawi Medical Journal |
| ISSN: | 1995-7262 |
| DOI: | 10.4314/mmj.v32i3.9 |
| Popis: | Background Toxoplasmosis in pregnancy could induce miscarriage, congenital anomalies in foetuses and encephalitis in HIV-infected people. Hence, there is a need to determine the prevalence of toxoplasmosis in HIV-infected pregnant women to inform clinicians about the significance of maternal toxoplasmosis in antenatal care.AimThis study aimed to determine the seroprevalence of Toxoplasma gondii infection, associated CD4+ T-cell profile and sociodemographic risk factors among pregnant women with or without HIV infection attending the University of Abuja Teaching Hospital, Abuja, Nigeria. MethodsThis hospital-based cross-sectional study involved blood samples collected from 160 HIV-infected and 160 HIV-seronegative pregnant women. These samples were analysed for anti-T. gondii (IgG and IgM) and CD4+ T-cell count using ELISA and flow cytometry, respectively. Sociodemographic variables of participants were collected using structured questionnaires. ResultsThe overall seroprevalence of anti-T. gondii IgG and IgM was 28.8% and 3.8%, respectively. The seroprevalence of anti-T. gondii IgG and IgM was 29.4% and 4.4%, respectively, among HIV-seropositive pregnant women and 28.1% and 3.1%, respectively, among HIV-seronegative women. There was no significant association between the seroprevalence of anti-T. gondii-IgG and anti-T. gondii-IgM with age, gestational age, education level, parity or place of residence of HIV-infected pregnant women (P > 0.05). However, there was significant association between the seroprevalence of anti-T. gondii-IgG (P = 0.03) and anti-T. gondii-IgM (P = 0.01) with education level. CD4+ T-cell count varied significantly between HIV-infected and HIV-uninfected pregnant women (P = 0.035). Conclusion In this study, the seroprevalence of anti-T. gondii IgG and IgM did not differ in HIV-seropositive or HIV-seronegative pregnant women. However, women with primary T. gondii and HIV coinfection had lower CD4+ T-cell count than those with toxoplasmosis monoinfection. |
| Databáze: | OpenAIRE |
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