Reduced lymphocyte subpopulations in patients with advanced or disseminated melanoma
| Autor: | Enrico Vigevani, Luigi Clocchiatti, Giuseppe Cartei, Silvio Donà, Mariella Sanzari, Angela Sibau, Mariella Giovannoni, Pier Guido Sala, Valentina Ceschia |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Skin Neoplasms Lymphocyte Antibodies Protozoan Fluorescent Antibody Technique Immunoglobulins Dermatology Antibodies Viral Immunoglobulin E Rubella CD19 Serology Leukocyte Count Antigen T-Lymphocyte Subsets Animals Humans Medicine Hypersensitivity Delayed Melanoma Serum Albumin Aged Skin Aged 80 and over biology business.industry Complement C3 Middle Aged medicine.disease medicine.anatomical_structure Delayed hypersensitivity Viruses Immunology biology.protein Female Neoplasm Recurrence Local Antibody business Toxoplasma |
| Zdroj: | Journal of the American Academy of Dermatology. 28:738-744 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/0190-9622(93)70103-z |
| Popis: | Studies have revealed many features of lymphocyte behavior in patients with malignant melanoma, but there are conflicting results.The aim of this study was to measure with easily reproducible assays the circulating lymphocytes and other immunologic aspects in 33 patients with advanced or disseminated malignant melanoma (MM).The following variables were measured: circulating monocytes; total lymphocytes; B (CD19) and T-cell subpopulations; CD3, CD4, and CD8, natural killer cells (anti-Leu-7+ or CD57 and anti-Leu-11+ or CD16) (cytofluorimetry); plasma levels of IgG, IgA, IgM, and IgE; complement fractions 3, 4, and 1Q; antibodies against foreign microorganisms (AaM) (adeno, herpes simplex, herpes zoster, measles, parotitis, cytomegalo, Epstein-Barr, and rubella viruses) and Toxoplasma; and cutaneous delayed hypersensitivity (CDH) to recall antigens (tetanus, diphtheria, Streptococcus, tuberculin, Proteus, Trichophyton, and Candida). We also studied 96 healthy persons, matched for age and geographic location, who were tested on the same days as the patients.In MM the number of total lymphocytes and subsets CD19, CD3, CD4, and CD8 was decreased from 25% to 40% (p0.001). The CD4/CD8 ratio increased (22%, p0.005) because of the relatively greater decrease of CD8. The CD57 and CD16 cells (expression of natural killer lymphocytes) were consistently reduced (30%; p0.002 to p0.003). C3 serum level was increased (30%; p0.001). Immunoglobulins, CDH, AaM, and all other tests were the same in the two groups.The single most important result seems to be a reduction of CD57 and CD16 cells in patients with advanced MM. |
| Databáze: | OpenAIRE |
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