Panton-Valentine Leukocidin-Producing Staphylococcus aureus Infection: A Case Series
| Autor: | André Silva-Pinto, Joana Sobrinho-Simões, Isabel A. Abreu, Beatriz Prista-Leão, Margarida Tavares, Paulo Andrade, Filipa Ceia, António Sarmento, José Manuel Pereira, Lurdes Santos, Raquel Duro |
|---|---|
| Přispěvatelé: | Instituto de Saúde Pública da Universidade do Porto |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Staphylococcus aureus medicine.drug_class 030106 microbiology Antibiotics Case Report Disease medicine.disease_cause virulence factor Travel abroad 03 medical and health sciences 0302 clinical medicine Internal medicine Intensive care Epidemiology medicine Recurrent disease Panton-Valentine leukocidin toxin 030212 general & internal medicine business.industry lcsh:Other systems of medicine bacterial infections and mycoses lcsh:RZ201-999 Infectious Diseases Panton–Valentine leukocidin business |
| Zdroj: | Infectious Disease Reports, Vol 12, Iss 14, Pp 61-69 (2020) Infectious Disease Reports |
| ISSN: | 2036-7449 |
| Popis: | Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) is associated with relapsing multifocal skin and soft tissue infections (SSTI), necrotizing pneumonia (NP) and severe musculoskeletal infections. Epidemiology is underknown and underdiagnosis is likely. Recent travel abroad, case clustering and relapsing disease are often reported. We reviewed all cases of PVL-SA infection diagnosed at our center, and found 21 cases over a 43-month period. Most patients were adult males, had relevant travel history, reported recurrent disease and presented with SSTI. Etiologic diagnosis took up to five years; meanwhile, 42% of patients had antibiotic treatments. Draining procedures were required in 43% of patients and intensive care support in 19%. All patients recovered. Methicillin-resistance prevalence was 24%. Only 2/13 decolonized patients had posterior relapsing SSTI, both with likely infected contacts. PVL-SA infection’s severity and impact are clear, even in small case series as ours. Physician awareness and active PVL-gene search are crucial for an adequate management. |
| Databáze: | OpenAIRE |
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