Copper‐Mediated Aminoquinoline‐Directed Radiofluorination of Aromatic C−H Bonds with K 18 F

Autor:	So Jeong Lee, Katarina J. Makaravage, Allen F. Brooks, Peter J. H. Scott, Melanie S. Sanford
Rok vydání:	2019
Předmět:	Agonist 010405 organic chemistry medicine.drug_class Chemistry Copper mediated General Medicine General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Aminoquinoline High specific activity medicine medicine.drug
Zdroj:	Angewandte Chemie International Edition. 58:3119-3122
ISSN:	1521-3773 1433-7851
Popis:	A Cu-mediated ortho-C-H radiofluorination of aromatic carboxylic acids that are protected as 8-aminoquinoline benzamides is described. The method uses K18 F and is compatible with a wide range of functional groups. The reaction is showcased in the high specific activity automated synthesis of the RARβ2 agonist [18 F]AC261066.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb9d19ea9f2a8af07745ce87d78ce26 https://doi.org/10.1002/anie.201812701 Zobrazit plný text záznamu Plný text