The peptides of α -aminosuberic acid I New intermediates for synthetic studies

Autor:	H. Stocker, V. Čeřovská, D. D. Laffan, M. Žertová, Petr Maloň, Vladimír Gut, E. Wünsch
Rok vydání:	2000
Předmět:	Calcitonin Peptide Biosynthesis Stereochemistry Chemistry Organic Chemistry Clinical Biochemistry Temperature Alpha (ethology) Tripeptide Optically active Biochemistry Amino Acids Dicarboxylic Enzyme catalysis Side chain Peptides
Zdroj:	Amino Acids. 18:219-227
ISSN:	1438-2199 0939-4451
DOI:	10.1007/s007260050019
Popis:	The paper describes the synthesis of alpha-aminosuberic acid derivatives suitable for the synthesis of peptides. These include Z-, Boc- and Fmoc-protection on the alpha-amino group, benzyl ester, Boc-hydrazide and Z-hydrazide as well as the free carboxylic function in the side chain, and methyl ester, benzyl ester or free alpha-carboxylic group. Their use is demonstrated on the synthesis of the respective derivatives of Asu-Val-Leu. The enzyme catalyzed reaction was successfully used both as a route to L-Asu from the D,L-compound as well as for the direct synthesis of the optically active tripeptide derivative from the Z-D,L-Asu-OH.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb91db7101db8ff86f6fdfa1d6d9ed5 https://doi.org/10.1007/s007260050019 Zobrazit plný text záznamu Full text from SpringerLink