Efficient Horner–Wadsworth–Emmons intramolecular cyclisation of a N-substituted phthalimide promoted by KF-Alumina: a general tool for the synthesis of functionalised isoindolinones

Autor:	Maria E. Fernandez, José V. Sinisterra, Andrés R. Alcántara, Clara I. Nova, Fernando J. Martinez, Vittorio Pace
Rok vydání:	2009
Předmět:	Phthalimide chemistry.chemical_compound chemistry Intramolecular force Organic Chemistry Drug Discovery Horner–Wadsworth–Emmons reaction Heterogeneous catalysis Biochemistry Medicinal chemistry Enone
Zdroj:	Tetrahedron Letters. 50:3050-3053
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2009.04.029
Popis:	An intramolecular Horner–Wadsworth–Emmons reaction promoted by KF-Alumina involving a N-substituted phthalimide, cleanly and efficiently furnishes an interesting α,β-unsaturated tricyclic enone which may undergo selective alkylations at the α′-position.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb8ae87b6c1dca191e38e8f12725198 https://doi.org/10.1016/j.tetlet.2009.04.029 Zobrazit plný text záznamu Full Text from ScienceDirect