Molecular interactions of the IGF system
| Autor: | Leah J. Cosgrove, Briony E. Forbes, Grant W. Booker, J C Wallace, Adam Denley |
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| Rok vydání: | 2005 |
| Předmět: |
Models
Molecular medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Molecular Sequence Data Immunology Biology Models Biological General Biochemistry Genetics and Molecular Biology Insulin-like growth factor Immune system Insulin-Like Growth Factor II Cell surface receptor Internal medicine medicine Animals Humans Immunology and Allergy Amino Acid Sequence Lymphopoiesis Insulin-Like Growth Factor I Receptor Bone growth Myogenesis Growth factor Receptors Somatomedin Cell biology Insulin-Like Growth Factor Binding Proteins Endocrinology Protein Binding |
| Zdroj: | Cytokine & Growth Factor Reviews. 16:421-439 |
| ISSN: | 1359-6101 |
| Popis: | The insulin-like growth factor (IGF) system is a complex network of two soluble ligands; several cell surface transmembrane receptors and six soluble high-affinity binding-proteins. The IGF system is essential for normal embryonic and postnatal growth, and plays an important role in the function of a healthy immune system, lymphopoiesis, myogenesis and bone growth among other physiological functions. Deregulation of the IGF system leads to stimulation of cancer cell growth and survival. In order to manipulate the IGF system in the treatment of certain disorders, we must understand the protein-protein interactions at a molecular level. The complex molecular interactions of the ligands and receptors of the IGF system underlie all the biological actions mentioned above and will be the focus of this review. |
| Databáze: | OpenAIRE |
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