Hepatic metabolism of vasoactive intestinal polypeptide during liver transplantation in the pig
| Autor: | P. Kirkegaard, C. Palnaes Hansen, Steen Boesby |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Portal Vein Swine Endocrinology Diabetes and Metabolism medicine.medical_treatment Vasoactive intestinal peptide Peptide hormone Liver transplantation Biology Liver Transplantation Transplantation Carotid Arteries Endocrinology Liver Gastrointestinal hormone Internal medicine medicine.artery medicine Animals Arterial blood Heart Atria Common carotid artery Drug metabolism Vasoactive Intestinal Peptide |
| Zdroj: | Journal of Endocrinological Investigation. 14:439-441 |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03346832 |
| Popis: | In order to investigate hepatic clearance of vasoactive intestinal polypeptide we measured its concentration in blood from the common carotid artery, right atrium and portal vein during orthotopic liver transplantation in six pigs. Just after laparotomy we found a significantly higher concentration of vasoactive intestinal polypeptide in portal plasma compared to that of the right atrium (p less than 0.05). This difference was soon eliminated by a fall in portal concentration, and, apart from fluctuations in portal concentration, no significant gradient between portal and atrial blood was recorded during the remaining part of the operation. When portal concentrations exceeded 30 pmol/l, the median reduction after transhepatic passage was 29% (range 16.8%-63.9%), while portal concentrations less than 30 pmol/l had a median reduction of only 6.3% (range 1.4%-16.5%) (p less than 0.05). No gradient between right atrial and systemic arterial blood was recorded. We suggest that a concentration-dependent clearance of splanchnic vasoactive intestinal polypeptide takes place in the porcine liver. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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