ANTIPLASMODIAL ACTIVITY OF KETOTIFEN-ARTEMETHER-LUMEFANTRINE ON PLASMODIUM BERGHEI INFECTED MICE
| Autor: | Chidi Emmanuel Ezerioha, UO Georgewill, Elias Adikwu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Ketotifen Artemether/lumefantrine biology Cholesterol business.industry 030231 tropical medicine 030106 microbiology Parasitemia Pharmacology medicine.disease biology.organism_classification Lumefantrine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry Chloroquine medicine Plasmodium berghei Artemether business medicine.drug |
| Zdroj: | International Journal of Research -GRANTHAALAYAH. 8:251-258 |
| ISSN: | 2350-0530 2394-3629 |
| DOI: | 10.29121/granthaalayah.v8.i11.2020.2439 |
| Popis: | Introduction: The development of new antimalarial drugs is time-consuming and costly, thus repurposing of drugs with initial indications for possible antimalarial indication is imperative. This study assessed the antiplasmodial effect of ketotifen (KT) in combination with artemether/lumefantrine (A/L) in Plasmodium bergei infected mice. Materials and Methods: Adult mice (25-30g) were parasitized with Plasmodium berghei, grouped and treated per oral (p.o) with KT (0.1mg/kg), A/L (2.3/13.7mg/kg) and KT/A/L daily in curative, suppressive and prophylactic studies. The negative control (NC) and the positive control (PC) were treated daily p.o with normal saline (0.2mL) and chloroquine (CQ) (10mg/kg) for 4 days respectively. After treatment, blood samples were collected and assessed for percentage parasitemia level, hematological and lipid parameters. Results: The curative, suppressive and prophylactic studies showed significant decreases in percentage parasitemia levels at KT (0.1mg/kg) (p |
| Databáze: | OpenAIRE |
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