Lymph node involvement by enteropathy-like indolent NK-cell proliferation
| Autor: | Nicolas Tinton, Mounir Trimech, Jean-Louis Dargent, Laurence de Leval |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Epstein-Barr Virus Infections Gastrointestinal Pathology medicine.medical_specialty Lymphoma Gastrointestinal Diseases Lymphoproliferative disorders Virus Pathology and Forensic Medicine medicine Humans Enteropathy Molecular Biology Lymph node business.industry Brief Report Gallbladder Cell Biology General Medicine medicine.disease Indolent NK-cell lymphoproliferative disorder Phenotype Lymphoproliferative Disorders Lymphomatoid gastropathy NK-cell enteropathy Gastrointestinal Tract Killer Cells Natural Intestinal Diseases medicine.anatomical_structure Lymph Nodes Lymph business Infiltration (medical) |
| Zdroj: | Virchows Archiv, vol. 478, no. 6, pp. 1197-1202 Virchows Archiv |
| Popis: | Natural killer (NK)-cell enteropathy (NKCE) and lymphomatoid gastropathy (LG) are closely related lymphoproliferative disorders (LPDs) composed of mature and Epstein–Barr virus (EBV)-negative NK-cells. Although these uncommon and indolent lymphoid proliferations mostly arise within the gastrointestinal (GI) tract as their designations implies, a few cases have been reported outside the GI tract. We hereby describe a unique case of lymph node infiltration by such EBV-negative NK-cell proliferation fortuitously found during routine examination of a gallbladder resected for biliary lithiasis. The histologic, phenotypic, and molecular features of this NK-cell proliferation, which were very similar if not identical to those previously reported in NKCE or LG, suggest that similar indolent EBV-negative NK-cell LPDs may also occasionally involve lymph nodes. |
| Databáze: | OpenAIRE |
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