Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice
| Autor: | Mickaël Naassila, Olivier Pierrefiche, Estelle Barbier, Catherine Ledent, Vincent Warnault, Chritophe Dubois, Hakim Houchi, Martine Daoust |
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| Přispěvatelé: | Groupe de Recherche sur l'alcool et les pharmacodépendances - UMR INSERM_S 1247 (GRAP), Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université libre de Bruxelles (ULB), Naassila, Mickael |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
Adenosine Drug Resistance Adenosine A2A receptor Anxiety Pharmacology MESH: Mice Knockout MESH: Genotype Mice Behavioral Neuroscience chemistry.chemical_compound Conditioning Psychological MESH: Behavior Animal MESH: Animals Sensitization MESH: Alcohol-Induced Disorders Nervous System Mice Knockout Behavior Animal Chemistry musculoskeletal neural and ocular physiology Brain MESH: Motor Activity medicine.anatomical_structure Neurology MESH: Drug Resistance MESH: Receptor Adenosine A2A [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Agonist MESH: Ethanol Genotype Receptor Adenosine A2A medicine.drug_class MESH: Motivation Motor Activity Anxiolytic MESH: Brain Alcohol-Induced Disorders Nervous System Species Specificity MESH: Mice Inbred C57BL Genetics medicine Animals MESH: Species Specificity [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH: Mice CGS-21680 Motivation Ethanol MESH: Anxiety Central Nervous System Depressants MESH: Conditioning (Psychology) MESH: Adenosine Conditioned place preference MESH: Male Mice Inbred C57BL Disease Models Animal MESH: Anti-Anxiety Agents Anti-Anxiety Agents Taste aversion MESH: Central Nervous System Depressants MESH: Disease Models Animal |
| Zdroj: | Genes, Brain and Behavior Genes, Brain and Behavior, Wiley, 2008, 7 (8), pp.887-98 Genes, Brain and Behavior, 2008, 7 (8), pp.887-98 |
| ISSN: | 1601-1848 1601-183X |
| Popis: | International audience; We have shown previously that mice lacking the adenosine A2A receptor (A2AR) generated on a CD1 background self-administer more ethanol and exhibit hyposensitivity to acute ethanol. We aimed to investigate if the increased propensity of A2A(-/-) mice to consume ethanol is associated with an altered sensitivity in the motivational properties of ethanol in the conditioned place preference (CPP) and conditioned taste aversion (CTA) paradigms and with an altered development of sensitization to the locomotor effects of ethanol. We also tested their sensitivity to the anxiolytic effects of ethanol. Our results show that A2A(-/-) mice produced on a CD1 background displayed a reduced ethanol-induced CPP and an increased sensitivity to the anxiolytic and locomotorstimulant effects of ethanol, but they did not show alteration in ethanol-induced CTA and locomotor sensitization. Ethanol-induced CPP, ethanol consumption and the locomotor effects of ethanol were also tested in A2A(-/-) mice produced on a C57BL/6J background. Our results emphasized the importance of the genetic background because alteration in ethanol consumption and preference, ethanol-induced CPP and locomotor-stimulant effects were not found in knockout mice produced on the alcohol-preferring C57BL/6J genetic background. Finally, the A2AR agonist, 2-p-(2-carboxyethyl)-phenylethylamino-50-N-ethylcarboxamidoadenosine hydrochloride (CGS 21680), reduced ethanol consumption and preference in C57BL/6J mice. In conclusion, A2AR deficiency in mice generated on a CD1 background leads to high ethanol consumption that is associated with an increased sensitivity to the locomotor-stimulant/anxiolytic effects of ethanol and a decrease in ethanol-induced CPP. |
| Databáze: | OpenAIRE |
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