Sucralfate induces proliferation of dermal fibroblasts and keratinocytes in culture and granulation tissue formation in full-thickness skin wounds
| Autor: | R M Burch, B A McMillan |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Keratinocytes
Male medicine.medical_specialty Cell type Skin wound Sucralfate Immunology Pharmacology Toxicology Dinoprostone Basal (phylogenetics) medicine Full thickness skin Animals Humans Pharmacology (medical) Prostaglandin E2 Cells Cultured Skin Gastrointestinal tract integumentary system Chemistry Interleukins Granulation tissue Rats Inbred Strains Fibroblasts Dermatology Rats medicine.anatomical_structure Granulation Tissue Wounds and Injuries Cell Division medicine.drug |
| Zdroj: | Agents and Actions. 34:229-231 |
| ISSN: | 1420-908X 0065-4299 |
| DOI: | 10.1007/bf01993288 |
| Popis: | Sucralfate is used to induce healing of gastrointestinal tract ulcers. We evaluated its potential utility in the healing of skin wounds. Initial experiments examined the effects of the sucralfate on proliferation of cultured dermal fibroblasts and keratinocytes. Sucralfate induced proliferation in quiescent cultures of both cell types. Additionally, sucralfate enhanced prostaglandin E2 synthesis in basal keratinocytes and in interleukin-1-stimulated keratinocytes and dermal fibroblasts. Basal interleukin-1 and 6 release were not affected by sucralfate, but the agent enhanced interleukin-1-stimulated interleukin-6 release from fibroblasts. When applied daily to full-thickness wounds in rats, sucralfate increased the thickness of granulation tissue when assessed at day 12. |
| Databáze: | OpenAIRE |
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