Humoral and T-cell response 12 months after the first BNT162b2 vaccination in solid organ transplant recipients and controls:Kinetics, associated factors, and role of SARS-CoV-2 infection
| Autor: | Omid Rezahosseini, Sebastian Rask Hamm, Line Dam Heftdal, Laura Pérez-Alós, Dina Leth Møller, Michael Perch, Johannes Roth Madsen, Annemette Hald, Cecilie Bo Hansen, Jose Juan Almagro Armenteros, Mia Marie Pries-Heje, Rasmus Bo Hasselbalch, Kamille Fogh, Ruth Frikke-Schmidt, Linda Maria Hilsted, Erik Sørensen, Sisse Rye Ostrowski, Zitta Barrella Harboe, Kasper Iversen, Henning Bundgaard, Søren Schwartz Sørensen, Allan Rasmussen, Peter Garred, Susanne Dam Nielsen |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Rezahosseini, O, Hamm, S R, Heftdal, L D, Pérez-Alós, L, Møller, D L, Perch, M, Madsen, J R, Hald, A, Hansen, C B, Armenteros, J J A, Pries-Heje, M M, Hasselbalch, R B, Fogh, K, Frikke-Schmidt, R, Hilsted, L M, Sørensen, E, Ostrowski, S R, Harboe, Z B, Iversen, K, Bundgaard, H, Sørensen, S S, Rasmussen, A, Garred, P & Nielsen, S D 2023, ' Humoral and T-cell response 12 months after the first BNT162b2 vaccination in solid organ transplant recipients and controls : Kinetics, associated factors, and role of SARS-CoV-2 infection ', Frontiers in Immunology, vol. 13, 1075423 . https://doi.org/10.3389/fimmu.2022.1075423 |
| Popis: | IntroductionWe investigated humoral and T-cell responses within 12 months after first BNT162b2 vaccine in solid organ transplant (SOT) recipients and controls who had received at least three vaccine doses. Furthermore, we compared the immune response in participants with and without previous SARS-CoV-2 infection.MethodsWe included adult liver, lung, and kidney transplant recipients, and controls were selected from a parallel cohort of healthcare workers.ResultsAt 12th-month, the IgG geometric mean concentrations (GMCs) (PConclusionIn conclusion, humoral and T-cell responses were inferior in SOT recipients without previous SARS-CoV-2 infection but comparable to controls in SOT recipients with previous infection. |
| Databáze: | OpenAIRE |
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