Bone Metastases in Neuroendocrine Neoplasms: From Pathogenesis to Clinical Management

Autor:	Altieri B., Di Dato C., Martini C., Sciammarella C., DI SARNO, ALFONSO, Colao A., Faggiano A., Albertelli M., AMBROSETTI, ENRICO MARIO, Bianchi A., Bottiglieri F., Campione S., Carra S., De Cicco F., Di Molfetta S., Fanciulli G., Ferone D., Ferrau F., Gallo M., Giannetta E., Grillo F., Maria E. G., Guadagno E., Guarnotta V., Isidori A., Lo Calzo F., Malandrino P., Messina E., Modica R., Muscogiuri G., Pizza G., Razzore P., Rizza L., Rubino M., Ruggeri R. M., Vitale G., Zatelli M. C.
Přispěvatelé:	Altieri, B., Di Dato, C., Martini, C., Sciammarella, C., DI SARNO, Alfonso, Colao, A., Faggiano, A., Albertelli, M., Ambrosetti, ENRICO MARIO, Bianchi, A., Bottiglieri, F., Campione, S., Carra, S., De Cicco, F., Di Molfetta, S., Fanciulli, G., Ferone, D., Ferrau, F., Gallo, M., Giannetta, E., Grillo, F., Maria, E. G., Guadagno, E., Guarnotta, V., Isidori, A., Lo Calzo, F., Malandrino, P., Messina, E., Modica, R., Muscogiuri, G., Pizza, G., Razzore, P., Rizza, L., Rubino, M., Ruggeri, R. M., Vitale, G., Zatelli, M. C.
Rok vydání:	2019
Předmět:	Oncology Cancer Research medicine.medical_specialty Prognosi Skeletal-related event education Skeletal related events 030209 endocrinology & metabolism Review lcsh:RC254-282 Pathogenesis Bone metastases Bone microenvironment Denosumab Epithelial-to-mesenchymal transition Microrna Neuroendocrine neoplasms Prognosis Skeletal-related events Treatment 03 medical and health sciences 0302 clinical medicine bone metastases Quality of life Internal medicine medicine neuroendocrine neoplasms microRNA treatment medicine.diagnostic_test business.industry digestive oral and skin physiology denosumab Retrospective cohort study lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens skeletal-related events Neuroendocrine neoplasm Clinical Practice Bone metastase stomatognathic diseases Positron emission tomography Curative treatment 030220 oncology & carcinogenesis epithelial-to-mesenchymal transition prognosis business bone microenvironment medicine.drug
Zdroj:	Cancers, Vol 11, Iss 9, p 1332 (2019) Cancers
ISSN:	2072-6694
DOI:	10.3390/cancers11091332
Popis:	Bone represents a common site of metastases for several solid tumors. However, the ability of neuroendocrine neoplasms (NENs) to localize to bone has always been considered a rare and late event. Thanks to the improvement of therapeutic options, which results in longer survival, and of imaging techniques, particularly after the introduction of positron emission tomography (PET) with gallium peptides, the diagnosis of bone metastases (BMs) in NENs is increasing. The onset of BMs can be associated with severe skeletal complications that impair the patient’s quality of life. Moreover, BMs negatively affect the prognosis of NEN patients, bringing out the lack of curative treatment options for advanced NENs. The current knowledge on BMs in gastro-entero-pancreatic (GEP) and bronchopulmonary (BP) NENs is still scant and is derived from a few retrospective studies and case reports. This review aims to perform a critical analysis of the evidence regarding the role of BMs in GEP- and BP-NENs, focusing on the molecular mechanisms underlining the development of BMs, as well as clinical presentation, diagnosis, and treatment of BMs, in an attempt to provide suggestions that can be used in clinical practice.
Databáze:	OpenAIRE
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