Dose-response study of dapiprazole HCl in the reversal of mydriasis induced by 2.5% phenylephrine
| Autor: | Tammy S. Hogan, Jimmy D. Bartlett, Dario A. Paggiarino, Danna D. McDANIEL, Kathryn K. Hart |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Mydriatics Adolescent medicine.medical_treatment Hyperemia Placebo Pupil Conjunctival Diseases Piperazines Phenylephrine Double-Blind Method Dapiprazole medicine Mydriasis Humans Pharmacology (medical) Antihypotensive agent Adrenergic alpha-Antagonists Pharmacology Cross-Over Studies Dose-Response Relationship Drug business.industry Accommodation Ocular Triazoles Crossover study Ophthalmology Regimen Anesthesia Area Under Curve Female medicine.symptom Ophthalmic Solutions business medicine.drug |
| Zdroj: | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 13(4) |
| ISSN: | 1080-7683 |
| Popis: | Dapiprazole HCL is currently available in the United States for reversal of diagnostic mydriasis. The recommended dosage for this indication is 2 drops followed 5 minutes later by 2 drops. We studied the dose-response profile and tolerance of three different treatment regimens: 1 drop alone, 1 drop followed by 1 additional drop 5 minutes later, and 2 drops followed by 2 additional drops 5 minutes later. Sixty normal male and female volunteers between 18 and 40 years of age were recruited for a double-masked, placebo-controlled, crossover study in which each eye of each subject was dilated with 2.5% phenylephrine. After one hour, one eye was treated with 0.5% dapiprazole, and the contralateral eye was treated with placebo. Each subject was treated with each of the three dapiprazole regimens in three different study sessions separated by at least 5 days (drug half-life in the eye is 5 hours). Analysis of AUC demonstrated no significant difference (P = 0.620) between the 1 drop regimen and the 2 + 2 regimen. A single drop of dapiprazole has a clinical effect equivalent to the 2 + 2 drop regimen in eyes dilated with 2.5% phenylephrine, which should improve the cost-effectiveness of this mydriolytic agent. |
| Databáze: | OpenAIRE |
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