Pre- and/or postsurgical administration of estradiol benzoate increases skin flap viability in female rats
| Autor: | Ján Durkáč, Petr Gál, Andrej Vrzgula, Iveta Tomková, Tomáš Vasilenko, Martin Novotný, Ivan Kováč, L. Lenhardt, Norbert Torma, Mikukáš Levkut, Martin Slezák |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Reconstructive surgery medicine.drug_class Ovariectomy Surgical Flaps Rats Sprague-Dawley chemistry.chemical_compound Necrosis medicine Hormone replacement therapy (male-to-female) Animals Survival rate Tissue Survival Wound Healing Estradiol business.industry Estrogen Replacement Therapy medicine.disease Surgery Rats Menopause Plastic surgery Disease Models Animal chemistry Estrogen Ovariectomized rat Estradiol benzoate Female business |
| Zdroj: | Aesthetic plastic surgery. 37(5) |
| ISSN: | 1432-5241 |
| Popis: | It has been shown that estrogens have a protective effect with regard to tissue ischemia. Therefore, in this macroscopic and histological investigation, the effect of estradiol benzoate on skin flap viability was studied in sham-operated and ovariectomized Sprague-Dawley rats. Three months prior to flap surgery a group of rats underwent ovariectomy, while the remaining animals underwent a sham operation. Subsequently, all rats had a 2 × 8-cm skin flap created on the dorsum. Rats were randomly divided into estradiol- or saline-treated groups. Treatment started either on the day of flap excision or 3 days prior to the surgery. Our results showed that administration of estradiol benzoate prior to and after flap surgery significantly decreases skin flap necrosis in both sham-operated and ovariectomized rats, with the highest survival rate in animals where treatment started 3 days prior to flap surgery. In conclusion, the observed protective effect of estradiol on skin flap viability could potentially be applied to plastic and reconstructive surgery in postmenopausal women. Nevertheless, further research is needed to explain the exact underlying mechanism and to find the optimal treatment protocol for human clinical practice. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink