Impact and effectiveness of the quadrivalent human papillomavirus vaccine:A systematic review of 10 years of real-world experience
| Autor: | Rosybel Drury, Christine Velicer, Stan L. Block, Gonzalo Perez, Alfred J. Saah, Darron R. Brown, Rituparna Das, Géraldine Dominiak-Felden, Barbara J. Kuter, Brianna Lindsay, Mark J. DiNubile, Suzanne M. Garland, Nubia Muñoz, Susanne K. Kjaer |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Pediatrics cervical cancer Drug exposure Uterine Cervical Neoplasms Gardasil/Silgard Disease Review Genital warts Human papillomavirus type 18 Human papillomavirus type 6 0302 clinical medicine Human Papillomavirus Recombinant Vaccine Quadrivalent Types 6 11 16 18 Observational study Medicine 030212 general & internal medicine Human papillomavirus type 11 CIN Review Articles Papillomaviridae Priority journal Cervical cancer Embase Vaccination HPV infection Condyloma acuminatum Medline virus diseases female genital diseases and pregnancy complications Precancer Infectious Diseases Condylomata Acuminata 030220 oncology & carcinogenesis Female Uterine cervix cancer Developed country genital warts Human Microbiology (medical) medicine.medical_specialty Immunology Human Papilloma Virus Vaccine Histopathology Papillomavirus infection Uterine cervix cytology 03 medical and health sciences Virology Humans HPV vaccination business.industry Public health Papillomavirus Infections medicine.disease Clinical effectiveness Systematic review business Uterine cervix tumor Wart virus vaccine |
| Zdroj: | Garland, S M, Kjaer, S K, Muñoz, N, Block, S L, Brown, D R, Dinubile, M J, Lindsay, B R, Kuter, B J, Perez, G, Dominiak-Felden, G, Saah, A J, Drury, R, Das, R & Velicer, C 2016, ' Impact and effectiveness of the quadrivalent human papillomavirus vaccine : A systematic review of 10 years of real-world experience ', Clinical Infectious Diseases, vol. 63, no. 4, pp. 519-527 . https://doi.org/10.1093/cid/ciw354 Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| DOI: | 10.1093/cid/ciw354 |
| Popis: | This systematic review assessed the global impact and effectiveness of quadrivalent human papillomavirus (HPV) vaccination on HPV infection and disease in real-world settings over a decade of use. Substantial reductions in HPV 6/11/16/18 infection, anogenital warts, and cervical lesions have been achieved. Prophylactic human papillomavirus (HPV) vaccination programs constitute major public health initiatives worldwide. We assessed the global effect of quadrivalent HPV (4vHPV) vaccination on HPV infection and disease. PubMed and Embase were systematically searched for peer-reviewed articles from January 2007 through February 2016 to identify observational studies reporting the impact or effectiveness of 4vHPV vaccination on infection, anogenital warts, and cervical cancer or precancerous lesions. Over the last decade, the impact of HPV vaccination in real-world settings has become increasingly evident, especially among girls vaccinated before HPV exposure in countries with high vaccine uptake. Maximal reductions of approximately 90% for HPV 6/11/16/18 infection, approximately 90% for genital warts, approximately 45% for low-grade cytological cervical abnormalities, and approximately 85% for high-grade histologically proven cervical abnormalities have been reported. The full public health potential of HPV vaccination is not yet realized. HPV-related disease remains a significant source of morbidity and mortality in developing and developed nations, underscoring the need for HPV vaccination programs with high population coverage. |
| Databáze: | OpenAIRE |
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