Vitamin D pathway gene polymorphisms, diet, and risk of postmenopausal breast cancer: a nested case-control study
| Autor: | Marjorie L. McCullough, Eugenia E. Calle, W. R. Diver, Michael J. Thun, Carmen Rodriguez, Robin M Bostick, Victoria L. Stevens, Heather Spencer Feigelson |
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| Rok vydání: | 2006 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Genotype Breast Neoplasms Biology Calcitriol receptor Polymorphism Single Nucleotide Breast cancer Risk Factors Internal medicine medicine Vitamin D and neurology Humans Taq Polymerase Vitamin D Deoxyribonucleases Type II Site-Specific Aged Cancer prevention Polymorphism Genetic Case-control study Odds ratio Middle Aged medicine.disease Diet Postmenopause Endocrinology Case-Control Studies Nested case-control study Female Research Article |
| Zdroj: | Breast Cancer Research |
| ISSN: | 1465-542X |
| Popis: | Introduction Vitamin D receptor (VDR) polymorphisms have been inconsistently associated with breast cancer risk. Whether risk is influenced by polymorphisms in other vitamin D metabolism genes and whether calcium or vitamin D intake modifies risk by genotype have not been evaluated. Methods We conducted a nested case-control study within the Cancer Prevention Study II Nutrition Cohort of associations between breast cancer and four VDR single-nucleotide polymorphisms (SNPs), Bsm1,Apa1,Taq1, and Fok1, a poly(A) microsatellite, and associated haplotypes (baTL and BAtS). We also examined one SNP in the 24-hydroxylase gene (CYP24A1) and two in the vitamin D-binding protein (group-specific component [GC]) gene. Participants completed a questionnaire on diet and medical history at baseline in 1992. This study includes 500 postmenopausal breast cancer cases and 500 controls matched by age, race/ethnicity, and date of blood collection. Results Incident breast cancer was not associated with any genotype examined. However, women with the Bsm1 bb SNP who consumed greater than the median intake of total calcium (≥902 mg/day) had lower odds of breast cancer compared to women with the Bb or BB genotype and less than the median calcium intake (odds ratio 0.61, 95% confidence interval 0.38 to 0.96; pinteraction = 0.01). Similar interactions were observed for Taq1 (T allele) and the poly(A) (LL) repeat. Conclusion We found no overall association between selected vitamin D pathway genes and postmenopausal breast cancer risk. However, certain VDR gene polymorphisms were associated with lower risk in women consuming high levels of calcium, suggesting that dietary factors may modify associations by VDR genotype. |
| Databáze: | OpenAIRE |
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