Effects of oral soy phosphatidylcholine on phagocytosis, arachidonate concentrations, and killing by human polymorphonuclear leukocytes
| Autor: | R H Lerman, J J Vitale, P W Jannace, J I Santos |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty food.ingredient Leukotriene B4 Neutrophils Phagocytosis Linoleic acid Phospholipid Medicine (miscellaneous) Biology Lecithin Linoleic Acid chemistry.chemical_compound food Internal medicine Phosphatidylcholine medicine Humans Calcimycin Safflower Oil Nutrition and Dietetics Arachidonic Acid Triglyceride Middle Aged Soybean Oil Endocrinology Biochemistry chemistry Linoleic Acids Phosphatidylcholines Arachidonic acid Female |
| Zdroj: | The American journal of clinical nutrition. 56(3) |
| ISSN: | 0002-9165 |
| Popis: | A dietary supplement of linoleic acid (LA) as soy phosphatidylcholine (PC) or as triglyceride on polymorphonuclear leukocyte (PMNL) functions, arachidonate (AA) concentrations, AA release, and leukotriene B4 (LTB4) generation was studied in normal adults. Study 1: Eight subjects were fed PC (27 g) or placebo for 3 d in a blinded crossover experiment with PMNL assays at baseline and 4, 7, and 14 d. Study 2: Subjects were fed equal quantities of LA as PC (18 g, n = 8), safflower (SF, n = 4), or soybean oil (SY, n = 4) with PMNL assays at baseline and 48 h. Study 1: PC increased PMNL phagocytosis and killing of Candida albicans twofold (P less than 0.001) and PMNL phospholipid AA content threefold (P less than 0.001); AA release after Candida albicans stimulation increased 5.3-fold, correlating with PMNL killing (r = 0.932) and phagocytosis (r = 0.872). Study 2: PC, but not SF or SY, produced changes similar to those of study 1. With PMNL exposure to calcium ionophore A23187 or N-formyl-methionyl-leucyl-phenylalanine, PC increased LTB4 generation. Phospholipid LA, in contrast to triglyceride LA, enhanced PMNL phospholipid AA, phagocytosis, and killing. |
| Databáze: | OpenAIRE |
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