A customized protocol to assess bone quality in the metacarpal head, metacarpal shaft and distal radius: a high resolution peripheral quantitative computed tomography precision study
| Autor: | Helen R. Buie, Heather S. McKay, Lynne M. Feehan, Linda T Li |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Bone density Coefficient of variation Metacarpal bones Early rheumatoid arthritis Arthritis Rheumatoid Young Adult Clinical Protocols Rheumatology Humans Medicine Orthopedics and Sports Medicine Quantitative computed tomography Ultra-ultra-distal radius Aged Bone mineral HR-pQCT medicine.diagnostic_test business.industry Repeated measures design Metacarpal Bones Middle Aged Precision Healthy Volunteers Peripheral Volumetric bone mineral density Metacarpal head Radius Metacarpal shaft Bone microstructure Orthopedic surgery Female Radiology Tomography X-Ray Computed Nuclear medicine business Research Article |
| Zdroj: | BMC Musculoskeletal Disorders |
| ISSN: | 1471-2474 |
| DOI: | 10.1186/1471-2474-14-367 |
| Popis: | Background High Resolution-Peripheral Quantitative Computed Tomography (HR-pQCT) is an emerging technology for evaluation of bone quality in Rheumatoid Arthritis (RA). However, there are limitations with standard HR-pQCT imaging protocols for examination of regions of bone commonly affected in RA. We developed a customized protocol for evaluation of volumetric bone mineral density (vBMD) and microstructure at the metacarpal head (MH), metacarpal shaft (MS) and ultra-ultra-distal (UUD) radius; three sites commonly affected in RA. The purpose was to evaluate short-term measurement precision for bone density and microstructure at these sites. Methods 12 non-RA participants, individuals likely to have no pre-existing bone damage, consented to participate [8 females, aged 23 to 71 y [median (IQR): 44 (28) y]. The custom protocol includes more comfortable/stable positioning and adapted cortical segmentation and direct transformation analysis methods. Dominant arm MH, MS and UUD radius scans were completed on day one; repeated twice (with repositioning) three to seven days later. Short-term precision for repeated measures was explored using intraclass correlational coefficient (ICC), mean coefficient of variation (CV%), root mean square coefficient of variation (RMSCV%) and least significant change (LSC%95). Results Bone density and microstructure precision was excellent: ICCs varied from 0.88 (MH2 trabecular number) to .99 (MS3 polar moment of inertia); CV% varied from 3 on 5 point scale. Conclusion In our facility, this custom protocol extends the potential for in vivo HR-pQCT imaging to assess, with high precision, regional differences in bone quality at three sites commonly affected in RA. Our methods are easy to adopt and we recommend other users of HR-pQCT consider this protocol for further evaluations of its precision and feasibility in their imaging facilities. |
| Databáze: | OpenAIRE |
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