Effects of depression pharmacotherapy in fertility treatment on conception, birth, and neonatal health: A systematic review
| Autor: | Leo E. Akioyamen, Noel O. Akioyamen, Hersimren Minhas, Alison C. Holloway, Diana Sherifali, Valerie H. Taylor |
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| Rok vydání: | 2016 |
| Předmět: |
Infertility
Adult Male medicine.medical_specialty Reproductive Techniques Assisted media_common.quotation_subject Population Fertility CINAHL Cochrane Library law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Pregnancy medicine Humans Infant Health 030212 general & internal medicine Psychiatry education Depression (differential diagnoses) media_common Randomized Controlled Trials as Topic Retrospective Studies education.field_of_study Depressive Disorder Major 030219 obstetrics & reproductive medicine business.industry Depression Infant Newborn Parturition medicine.disease Antidepressive Agents Psychiatry and Mental health Clinical Psychology Fertilization Female business |
| Zdroj: | Journal of psychosomatic research. 84 |
| ISSN: | 1879-1360 |
| Popis: | Objectives While antidepressant medications are currently used during conception, gestation and post-partum, considerable uncertainty exists regarding the benefits and harms conferred to mothers and their offspring. A significant body of evidence has focused on antidepressant use during pregnancy and post-partum. However, it is difficult to know if this translates to specific populations. Women receiving treatment for infertility are especially vulnerable to symptoms of depression and adverse perinatal outcomes. This systematic review aimed to determine the effects of antidepressants taken during the perinatal period by women receiving fertility treatment on conception, birth, and long-term maternal and child health outcomes. Methods We searched MEDLINE, EMBASE, CINAHL, the Cochrane Library, PsycINFO, ProQuest Dissertation & Theses, and Pubmed databases from January 1950 to November 2015. Articles were screened for inclusion independently by two reviewers. Studies were included if they enrolled women of reproductive age exposed to pharmacotherapy for depression and infertility at any point during the perinatal period. Results A total of 8587 unique citations, and 83 full-text articles were reviewed. Of these, two randomized controlled trials and two retrospective chart reviews were included in the narrative synthesis. While most studies reported on assisted reproduction processes and birth outcomes, none examined long-term impacts on maternal–child health. The few included studies did not find that antidepressant use by women receiving fertility therapy impacted gamete quality or pregnancy success. Conclusions Currently, no studies address whether pharmacotherapy for the treatment of depression in women undergoing assisted reproduction affects their health or that of their offspring long-term. It appears that much like antidepressant use in fertile women, there are risks associated with both antidepressant use and untreated depression. Decisions regarding the treatment of depression should be made taking into account clinical presentation and illness severity. Given the complexities of conducting research in this population, future research should attempt to leverage health registry data, to increase sample sizes and follow mothers and children longitudinally. |
| Databáze: | OpenAIRE |
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