Comparison Study of Polysomnographic Features in Multiple System Atrophy-cerebellar Types Combined with and without Rapid Eye Movement Sleep Behavior Disorder
| Autor: | Yuping Wang, Cunjiang Li, Shuqin Zhan, Yan Ding, Hongxing Wang, Yue-Qing Hu |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Movement disorders Cerebellar Ataxia Polysomnography Rapid eye movement sleep lcsh:Medicine REM Sleep Behavior Disorder Behavior Disorder Audiology Sleep medicine 03 medical and health sciences Behavior disorder 0302 clinical medicine Atrophy Internal medicine mental disorders medicine Humans Multiple System Atrophy-cerebellar Types Rapid Eye Movement Sleep Video-polysomnography medicine.diagnostic_test business.industry lcsh:R Eye movement General Medicine Middle Aged Multiple System Atrophy medicine.disease Sleep in non-human animals nervous system diseases 030104 developmental biology Female Original Article medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Chinese Medical Journal Chinese Medical Journal, Vol 129, Iss 18, Pp 2173-2177 (2016) |
| ISSN: | 0366-6999 |
| DOI: | 10.4103/0366-6999.189903 |
| Popis: | Background: The brain stem is found to be impaired in multiple system atrophy-cerebellar types (MSA-C). Rapid eye movement (REM) sleep behavior disorder (RBD) is reported as a marker of progressive brain stem dysfunction. Few systematic studies about the sleep disturbances in MSA-C patients combined with or without RBD were reported. This study aimed to explore the polysomnographic (PSG) features of sleep disturbances between MSA-C patients with and without RBD. Methods: Totally, 46 MSA-C patients (23 with RBD, and 23 without RBD) were enrolled in this study. All patients underwent a structured interview for their demographic data, history of sleep pattern, and movement disorders; and then, overnight video-PSG was performed in each patient. All the records were evaluated by specialists at the Sleep Medicine Clinic for RBD and the Movement Disorder Clinic for MSA-C. The Student's t -test, Mann-Whitney U -test for continuous variables, and the Chi-square test for categorical variables were used in this study. Results: MSA-C patients with RBD had younger visiting age (52.6 ± 7.4 vs. 56.7 ± 6.0 years, P = 0.046) and shorter duration of the disease (12.0 [12.0, 24.0] vs. 24.0 [14.0, 36.0] months, P = 0.009) than MSA-C patients without RBD. MSA-C with RBD had shorter REM sleep latency (111.7 ± 48.2 vs. 157.0 ± 68.8 min, P = 0.042), higher percentage of REM sleep (14.9% ±4.0% vs. 10.0% ± 3.2%, P = 0.019), and lower Stage I (9.5% ±7.2% vs. 15.9% ±8.0%, P = 0.027) than MSA-C without RBD. Moreover, MSA-C patients with RBD had more decreased sleep efficiency (52.4% ±12.6% vs. 65.8% ±15.9%, P = 0.029) than that without RBD. Conclusions: In addition to the RBD, MSA-C patients with RBD had other more severe sleep disturbances than those without RBD. The sleep disorders of MSA patients might be associated with the progress of the disease. |
| Databáze: | OpenAIRE |
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