Synthesis and biological study of medicinally important Mannich bases derived from 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide
| Autor: | Anju Das Manikpuri, Sheela Joshi, Prapti Tiwari |
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| Rok vydání: | 2007 |
| Předmět: |
Magnetic Resonance Spectroscopy
Pasteurella multocida Naphthacenes Spectrophotometry Infrared medicine.drug_class Clinical Biochemistry Pharmaceutical Science Carboxamide Mannich base Biochemistry Chemical synthesis Lethal Dose 50 Mannich Bases Mice chemistry.chemical_compound Drug Discovery medicine Animals Organic chemistry Molecular Biology Mannich reaction Antibacterial agent chemistry.chemical_classification Organic Chemistry Anti-Bacterial Agents Sulfonamide Salmonella enteritidis chemistry Molecular Medicine Indicators and Reagents Spectrophotometry Ultraviolet Antibacterial activity Derivative (chemistry) |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 17:645-648 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2006.11.001 |
| Popis: | The paper describes synthesis and antibacterial study of biologically active Mannich bases of carboxamide derivative employing Mannich reaction of 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a pentahydroxy naphthacene carboxamide with various sulfonamides/secondary amines .They were analysed by elemental analysis and characterized by UV, IR and 1 H NMR spectroscopic studies. The Mannich bases were screened for antibacterial activity against various gram-negative bacteria at various concentrations and were analysed statistically. The result has shown that the compounds are quite active against pathogens under study and were non-toxic. All the synthesized compounds were found to be low lethal as ascertained by LD 50 test. |
| Databáze: | OpenAIRE |
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