Mechanistic medicine: Novel strategies for clinical trials

Autor:	Gerald Siu, Andrea A. Itano, Martin Sims
Rok vydání:	2010
Předmět:	Clinical Trials as Topic medicine.medical_specialty education.field_of_study Drug discovery business.industry medicine.medical_treatment Immunology Population Target engagement Immunosuppression Pharmacology Autoimmune Diseases Clinical trial Drug Design medicine Humans Immunology and Allergy Effective treatment Dosing Intensive care medicine business education Immunosuppressive Agents
Zdroj:	Autoimmunity. 43:560-571
ISSN:	1607-842X 0891-6934
Popis:	Autoimmune diseases affect a significant proportion of the population and the development of therapeutics able to manipulate the immune response to deliver effective treatment in these diseases is an accepted approach for drug discovery. This article will focus on recent strategies for achieving selectivity through target choice, thus reducing overall clinical immunosuppression. We review the use of mechanistic pharmacodynamic assays preclinically and in the clinic to assess target engagement and to build the relationship between target coverage and efficacy, to guide dosing. Finally, we review the use of monogenic diseases to deliver proof of mechanism clinical studies and to identify patient populations in larger autoimmune diseases that may be sensitive to intervention with a specific therapeutic.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca4b334edd3f29b48373ba46bcf6e50 https://doi.org/10.3109/08916931003674782 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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