Episodic sitewise positive selection on the signal recognition particle protein Ffh in Actinobacteria
| Autor: | Yong-Quan Li, Shan-Zhen Li, Xin Chen, Xue-Ling Shen |
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| Rok vydání: | 2010 |
| Předmět: |
Silent mutation
Biophysics Biochemistry Actinobacteria Evolution Molecular Bacterial Proteins Structural Biology Genetics Protein translocation Selection Genetic Molecular Biology Episodic evolution Signal recognition particle biology Core component Positive selection Cell Biology biology.organism_classification PAML Protein Transport Mutation Ffh Signal Recognition Particle |
| Zdroj: | FEBS Letters. 584:3975-3978 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/j.febslet.2010.07.058 |
| Popis: | In this work, we report a case of episodic sitewise positive selection acting on the highly conserved SRP protein Ffh in Actinobacteria. An elevated non-synonymous to synonymous mutation ratio (ω) was observed along the non-terminal branches of the species tree, which contained 11 Actinobacteria species, where positively selected residues were frequently observed within the signal sequence-binding domain. Together with the estimated lineage-specific ω ratios for several core components in the major protein translocation systems, our data suggest that this positive selection might be partially driven by the diversification of signal sequences. |
| Databáze: | OpenAIRE |
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