Inhibitors of the renin-angiotensin system ameliorates clinical and pathological aspects of experimentally induced nephrotoxic serum nephritis

Autor: E. G. Petersen, Maria Elm Ougaard, Henrik Jeldtoft Jensen, I. D. Thuen, Peter Helding Kvist
Rok vydání: 2018
Předmět:
030232 urology & nephrology
Angiotensin-Converting Enzyme Inhibitors
030204 cardiovascular system & hematology
Pharmacology
Kidney
urologic and male genital diseases
lcsh:RC870-923
Critical Care and Intensive Care Medicine
Losartan
Renin-Angiotensin System
Pathogenesis
Angiotensin Receptor Antagonists
Mice
03 medical and health sciences
0302 clinical medicine
Enalapril
Laboratory Study
Renin–angiotensin system
Albuminuria
Animals
Medicine
Pathological
Nephrotoxic serum nephritis
Nephritis
business.industry
General Medicine
lcsh:Diseases of the genitourinary system. Urology
medicine.disease
female genital diseases and pregnancy complications
angiotensin II receptor blocker
Disease Models
Animal
angiotensin-converting enzyme inhibitor
Nephrology
pathology
business
Glomerular Filtration Rate
Kidney disease
Zdroj: Renal Failure, Vol 40, Iss 1, Pp 640-648 (2018)
Ougaard, M E, Jensen, H E, Thuen, I D, Petersen, E G & Kvist, P H 2018, ' Inhibitors of the renin-angiotensin system ameliorates clinical and pathological aspects of experimentally induced nephrotoxic serum nephritis ', Renal Failure, vol. 40, no. 1, pp. 640-648 . https://doi.org/10.1080/0886022X.2018.1533867
Renal Failure
ISSN: 1525-6049
0886-022X
Popis: INTRODUCTION: Chronic kidney disease (CKD) is a global health concern, but the current treatments only slow down the progression. Thus an improved understanding of the pathogenesis and novel treatments of CKD are needed. The nephrotoxic nephritis (NTN) model has the potential to study the pathogenesis of CKD as it resembles human CKD. The classical treatments with angiotensin II receptor blocker (ARB) or the angiotensin-converting enzyme inhibitor (ACE I) have shown a clinical effect in CKD.METHODS: We characterized the disease development in the NTN model over 11 weeks by investigating functional and histopathological changes. We tested doses of 15 and 30 mg/kg/day enalapril and losartan in the NTN model in order to investigate the effect of inhibiting the renin-angiotensin-system (RAS).RESULTS: The NTN model displayed albuminuria peaking on days 6-7, mesangial expansion (ME), renal fibrosis, inflammation and iron accumulation peaking on day 42. However, albuminuria, ME, renal fibrosis and inflammation were still significantly present on day 77, suggesting that the NTN model is useful for studying both the acute and chronic disease phases. Enalapril and losartan significantly enhanced the glomerular filtration rate (GFR) and decreased albuminuria, ME, renal fibrosis and inflammation of NTN-induced kidney disease in mice.CONCLUSIONS: This is the first study showing a comprehensive pathological description of the chronic features of the murine NTN model and that inhibiting the RAS pathway show a significant effect on functional and morphological parameters.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje