Induction of T cell responses to the invariant chain derived peptide CLIP in mice immunized with the group 1 allergen of house dust mite
| Autor: | Charlotte Hetzel, John D. Hayball, Nanna M. Kristensen, J. R. Lamb, Timothy Bourne, Gerard F. Hoyne |
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| Rok vydání: | 1996 |
| Předmět: |
T cell
T-Lymphocytes Immunology Molecular Sequence Data Cross Reactions Lymphocyte Activation Epitope Mice Antigen Antigens CD MHC class I medicine Immunology and Allergy Cytotoxic T cell Animals Humans Amino Acid Sequence Antigens Dermatophagoides Antigen-presenting cell Cells Cultured Glycoproteins MHC class II Mites biology Sequence Homology Amino Acid Vaccination H-2 Antigens Histocompatibility Antigens Class II General Medicine T lymphocyte Allergens Molecular biology Antigens Differentiation B-Lymphocyte Mice Inbred C57BL medicine.anatomical_structure biology.protein Female |
| Zdroj: | International immunology. 8(7) |
| ISSN: | 0953-8178 |
| Popis: | In this study we demonstrate that immunization of H-2(b) mice with the allergen Der p 1 induces MHC class II restricted T cells that proliferate to residues 15-29 of Der p 1 (p15-29) and to the murine MHC class II-associated invariant chain derived peptide (CLIP). T cells from naive H-2(b) mice and those immunized with murine CLIP fail to respond to either CLIP or p15-29. T cell lines and clones reactive with p15-29 strongly proliferate in response to splenic antigen-presenting cells (APC) from normal H-2(b) mice but show reduced proliferation to APC from invariant chain deficient mice. Furthermore, T cells isolated from Der p 1 primed mice and expanded on H-2(b) spleen cells in the absence of the p15-29 epitope retained specificity for both p15-29 and CLIP, suggesting that naturally presented self components can act as mimetic peptides and may maintain T cell memory to foreign antigens. |
| Databáze: | OpenAIRE |
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