Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media
| Autor: | Youngki Kim, Jizhen Lin, George L. Adams, Hirokazu Kawano, Samuel B. Ho, Atsushi Haruta, S. K. Juhn |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Ear Middle Mucin 2 Biology Epithelium Proinflammatory cytokine Rats Sprague-Dawley Paracrine signalling Internal medicine medicine Immunology and Allergy Animals Autocrine signalling Mucin-2 Dose-Response Relationship Drug Otitis Media with Effusion Tumor Necrosis Factor-alpha Mucin Mucins Rats Up-Regulation Infectious Diseases medicine.anatomical_structure Endocrinology Cytokine Gene Expression Regulation Immunology Middle ear Tumor necrosis factor alpha |
| Zdroj: | The Journal of infectious diseases. 182(3) |
| ISSN: | 0022-1899 |
| Popis: | Mucoid otitis media (MOM) is characterized by viscous fluid, high in mucin concentration, which accumulates in the middle ear cavity. Recent studies suggest that initial infection in the middle ear cleft may be key to the development of MOM. However, factors of the initial infection attributed to the stimulation of mucin production are not clearly understood. This study demonstrated that tumor necrosis factor (TNF)-alpha, a proinflammatory cytokine in mucoid effusion, markedly increased Muc2 mucin mRNA expression in middle ear epithelium, in a time- and dose-dependent manner. Parallel to this was a marked increase in mucin glycoprotein in middle ear fluid. Also, TNF-alpha demonstrated an autocrine and/or paracrine effect on the expression of endogenous TNF-alpha gene in the middle ear, which may contribute to the production of mucin in this study. These findings suggest that TNF-alpha plays an important role in the development of MOM by stimulating mucin metabolism. |
| Databáze: | OpenAIRE |
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