DNA damage induced by exposure to pesticides in children of rural areas in Paraguay

Autor: Marta Almada Denis, Domingo Santiago Avalos, Deidamia Mercedes Franco de Diana, Boris Alexei Thielmann Arbo, Cristina Coronel Ovelar, Ramón Corvalan, Jaime Alfredo Segovia Abreu, Stela Benitez Leite, María José Samaniego Royg
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Rural Population
DNA damage
biomonitoring - buccal micronucleus cytome assay - children - comet assay - dna - pesticides
030106 microbiology
Population
Physiology
lcsh:Medicine
General Biochemistry
Genetics and Molecular Biology
Group B
03 medical and health sciences
0302 clinical medicine
children
comet assay
Diabetes mellitus
medicine
Cholinesterases
Humans
030212 general & internal medicine
education
buccal micronucleus cytome assay
Child
education.field_of_study
Micronucleus Tests
Cell Death
business.industry
lcsh:R
Mouth Mucosa
Agriculture
General Medicine
DNA
pesticides
Environmental Exposure
Pesticide
medicine.disease
Plants
Genetically Modified
Comet assay
Paraguay
Child
Preschool
Toxicity
Biomonitoring
Original Article
Female
Micronucleus
business
Biomarkers
DNA Damage
Zdroj: Indian Journal of Medical Research, Vol 150, Iss 3, Pp 290-296 (2019)
The Indian Journal of Medical Research
ISSN: 0971-5916
Popis: Background & objectives: Chronic exposure to pesticides can damage DNA and lead to cancer, diabetes, respiratory diseases and neurodegenerative and neurodevelopment disorders. The objective of this study was to determine the frequency of DNA damage through the comet assay and micronucleus (MN) test in two groups of children, under 10 yr of age living in rural Paraguay and in relation to pesticide exposure. Methods: Two groups of 5 to 10 yr old children were formed; the exposed group (group A, n=43), born and currently living in a community dedicated to family agriculture and surrounded by transgenic soybean crops, and the control group (group B, n=41), born and living in a community dedicated to family agriculture with biological control of pests. For each child, 2000 cells were studied for the MN test and 200 cells for the comet assay. Results: The comparison between exposed and control children revealed significant differences in biomarkers studied for the measurement of genetic damage (cell death and DNA damage). The median of MN was higher in the exposed group (6 vs. 1) (P
Databáze: OpenAIRE
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