Metabolism Regulation and Redox State: Insight into the Role of Superoxide Dismutase 1
Autor: | Mariarosaria Santillo, Bruna Guida, Simona Damiano, Paolo Mondola, Giuliana La Rosa, Concetta Sozio, Raffaella Faraonio |
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Přispěvatelé: | Damiano, S., Sozio, C., La Rosa, G., Guida, B., Faraonio, R., Santillo, M., Mondola, P. |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
amyotrophic lateral sclerosis
Cell Respiration SOD1 Review Nutrient sensing Mitochondrion Lymphocyte Activation Antioxidants Catalysis Inorganic Chemistry Superoxide dismutase lcsh:Chemistry Superoxide Dismutase-1 superoxide dismutase 1 Animals Humans Physical and Theoretical Chemistry redox signaling Molecular Biology lcsh:QH301-705.5 Spectroscopy Amyotrophic lateral sclerosi chemistry.chemical_classification reactive oxygen species Reactive oxygen species biology TOR Serine-Threonine Kinases Organic Chemistry nutritional and metabolic diseases General Medicine Metabolism Diet Computer Science Applications Cell biology Mitochondria Metabolic pathway Cholesterol chemistry lcsh:Biology (General) lcsh:QD1-999 biology.protein cholesterol metabolism Reactive oxygen specie Energy Metabolism Flux (metabolism) metabolism |
Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 6606, p 6606 (2020) International Journal of Molecular Sciences |
ISSN: | 1661-6596 1422-0067 |
Popis: | Energy metabolism and redox state are strictly linked; energy metabolism is a source of reactive oxygen species (ROS) that, in turn, regulate the flux of metabolic pathways. Moreover, to assure redox homeostasis, metabolic pathways and antioxidant systems are often coordinately regulated. Several findings show that superoxide dismutase 1 (SOD1) enzyme has effects that go beyond its superoxide dismutase activity and that its functions are not limited to the intracellular compartment. Indeed, SOD1 is secreted through unconventional secretory pathways, carries out paracrine functions and circulates in the blood bound to lipoproteins. Striking experimental evidence links SOD1 to the redox regulation of metabolism. Important clues are provided by the systemic effects on energy metabolism observed in mutant SOD1-mediated amyotrophic lateral sclerosis (ALS). The purpose of this review is to analyze in detail the involvement of SOD1 in redox regulation of metabolism, nutrient sensing, cholesterol metabolism and regulation of mitochondrial respiration. The scientific literature on the relationship between ALS, mutated SOD1 and metabolism will also be explored, in order to highlight the metabolic functions of SOD1 whose biological role still presents numerous unexplored aspects that deserve further investigation. |
Databáze: | OpenAIRE |
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