Metabolism Regulation and Redox State: Insight into the Role of Superoxide Dismutase 1

Autor: Mariarosaria Santillo, Bruna Guida, Simona Damiano, Paolo Mondola, Giuliana La Rosa, Concetta Sozio, Raffaella Faraonio
Přispěvatelé: Damiano, S., Sozio, C., La Rosa, G., Guida, B., Faraonio, R., Santillo, M., Mondola, P.
Jazyk: angličtina
Rok vydání: 2020
Předmět:
amyotrophic lateral sclerosis
Cell Respiration
SOD1
Review
Nutrient sensing
Mitochondrion
Lymphocyte Activation
Antioxidants
Catalysis
Inorganic Chemistry
Superoxide dismutase
lcsh:Chemistry
Superoxide Dismutase-1
superoxide dismutase 1
Animals
Humans
Physical and Theoretical Chemistry
redox signaling
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Amyotrophic lateral sclerosi
chemistry.chemical_classification
reactive oxygen species
Reactive oxygen species
biology
TOR Serine-Threonine Kinases
Organic Chemistry
nutritional and metabolic diseases
General Medicine
Metabolism
Diet
Computer Science Applications
Cell biology
Mitochondria
Metabolic pathway
Cholesterol
chemistry
lcsh:Biology (General)
lcsh:QD1-999
biology.protein
cholesterol metabolism
Reactive oxygen specie
Energy Metabolism
Flux (metabolism)
metabolism
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 6606, p 6606 (2020)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: Energy metabolism and redox state are strictly linked; energy metabolism is a source of reactive oxygen species (ROS) that, in turn, regulate the flux of metabolic pathways. Moreover, to assure redox homeostasis, metabolic pathways and antioxidant systems are often coordinately regulated. Several findings show that superoxide dismutase 1 (SOD1) enzyme has effects that go beyond its superoxide dismutase activity and that its functions are not limited to the intracellular compartment. Indeed, SOD1 is secreted through unconventional secretory pathways, carries out paracrine functions and circulates in the blood bound to lipoproteins. Striking experimental evidence links SOD1 to the redox regulation of metabolism. Important clues are provided by the systemic effects on energy metabolism observed in mutant SOD1-mediated amyotrophic lateral sclerosis (ALS). The purpose of this review is to analyze in detail the involvement of SOD1 in redox regulation of metabolism, nutrient sensing, cholesterol metabolism and regulation of mitochondrial respiration. The scientific literature on the relationship between ALS, mutated SOD1 and metabolism will also be explored, in order to highlight the metabolic functions of SOD1 whose biological role still presents numerous unexplored aspects that deserve further investigation.
Databáze: OpenAIRE
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