Persistent fontanelles in Chihuahuas. Part II : Association with craniocervical junction abnormalities, syringomyelia, and ventricular volume

Autor: Jouni Junnila, Anna Mariam Kiviranta, Anu K. Lappalainen, Tarja S. Jokinen, Clare Rusbridge
Přispěvatelé: Equine and Small Animal Medicine, Departments of Faculty of Veterinary Medicine, Staff Services, Petbone – ortopedia, fysioterapia, kivunlievitys, Helsinki One Health (HOH), Doctoral Programme in Clinical Veterinary Medicine
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Chiari‐like malformation
040301 veterinary sciences
Veterinary medicine
Chiari‐
Dilated fourth ventricle
Standard Article
413 Veterinary science
Fourth ventricle
0403 veterinary science
03 medical and health sciences
Dogs
0302 clinical medicine
Internal medicine
SF600-1100
medicine
Animals
craniocervical junction
Dog Diseases
like malformation
ventriculomegaly
General Veterinary
medicine.diagnostic_test
business.industry
Fontanelle
Magnetic resonance imaging
04 agricultural and veterinary sciences
medicine.disease
Magnetic Resonance Imaging
Standard Articles
syringomyelia
Confidence interval
Arnold-Chiari Malformation
Cross-Sectional Studies
medicine.anatomical_structure
Neurology
Ventricle
Cardiology
SMALL ANIMAL
business
030217 neurology & neurosurgery
Syringomyelia
Ventriculomegaly
Zdroj: Journal of Veterinary Internal Medicine, Vol 35, Iss 4, Pp 1848-1856 (2021)
Journal of Veterinary Internal Medicine
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.16123
Popis: Background Persistent fontanelles (PFs) are, in Chihuahuas, almost ubiquitous. Furthermore, Chihuahuas are predisposed to other craniomorphological abnormalities, including syringomyelia (SM), ventriculomegaly, and craniocervical junction (CCJ) overcrowding resulting in neural tissue deviation. It is, however, undetermined if PFs are more common in dogs with these structural abnormalities, and their etiology is unknown. Hypothesis/objectives Persistent fontanelles are more numerous and larger in Chihuahuas with low body weight, older age, SM, dilated fourth ventricle, ventriculomegaly, and CCJ overcrowding. Animals Fifty client-owned Chihuahuas. Methods Cross-sectional study evaluating the association of both the number of cranial sutures affected by PFs (NAS) and total fontanelle area (TFA), based on computed tomography with SM, fourth ventricle dilatation, lateral ventricle volume, and extent of neural tissue compression at the CCJ based on magnetic resonance images. Results The NASs was higher and TFA larger in dogs with low body weight (NAS: P = .007; 95% confidence interval [CI] = 0.384-0.861; TFA: P = .002; 95% CI = -1.91 to -0.478), larger lateral ventricles (NAS: P ≤ .001; 95% CI = 1.04-1.15; TFA: P ≤ .001; 95% CI = 0.099-0.363), and more severe neural tissue compression at the CCJ (NAS: P ≤ .001; 95% CI = 1.26-2.06; TFA: P = .03; 95% CI = 0.066-1.13). Similarly, dogs with SM (NAS: P = .004; 95% CI = 1.26-3.32; TFA: mean ± SD, 130 ± 217 mm2 ; P = .05) had higher NAS and larger TFA than did dogs without SM (43.7 ± 61.0 mm2 ). Age was not associated with NAS (P = .81; 95% CI = 0.989-1.01) or TFA (P = .33; 95% CI = -0.269 to 0.092). Conclusions and clinical importance Persistent fontanelles are associated with small size, SM, ventriculomegaly, and CCJ overcrowding.
Databáze: OpenAIRE
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