Spot Urinary Albumin-to-Creatinine Ratio: A Novel Marker for Detecting Fetomaternal Outcomes and Complications in Preeclamptic Women

Autor: Deepa Borgohain, Sowmya Mahesh
Rok vydání: 2019
Předmět:
Zdroj: J Obstet Gynaecol India
ISSN: 0975-6434
0971-9202
DOI: 10.1007/s13224-019-01264-w
Popis: INTRODUCTION: Preeclampsia is a multisystem endothelial disease leading to glomeruloendotheliosis with endothelial leak causing significant proteinuria. It is associated with high maternal and fetal risks and fetomaternal morbidity and mortality. Spot urinary albumin-to-creatinine ratio (ACR) leads to earlier detection of glomerular damage leading to prompt management of preeclamptic patients. AIMS AND OBJECTIVES: To study the correlation between fetomaternal outcomes of preeclamptic patients with spot urinary ACR. MATERIALS AND METHODS: Spot urinary ACR was measured in 70 consecutive patients with preeclampsia in Assam Medical College, Dibrugarh. The best cutoff value to differentiate between significant and insignificant proteinuria was calculated. Mean spot urinary ACR was calculated in all maternal outcomes (mode of onset of labor and mode of delivery), and maternal complications (elevated liver enzymes, renal insufficiency, severe hypertension, coagulation disturbances and thrombocytopenia, antepartum and postpartum hemorrhage) and fetal complications and outcomes (birth weight, Apgar score, IUGR, need for resuscitation, NICU requirement, neonatal sepsis, jaundice and mortality) and the correlation were studied. RESULTS: The best cutoff value to differentiate significant and insignificant proteinuria was calculated as 291.9 mg/g beyond which adverse fetomaternal outcomes and complications were seen. All maternal and fetal outcomes and complications had high mean spot urinary ACR and were found to be significant (p
Databáze: OpenAIRE
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