Relationship between ghrelin and obestatin levels and ghrelin/obestatin ratio in patients with asthma
| Autor: | B. Bozkurt, Harun Karamanli, Deniz Kızılırmak |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Waist Critical Care and Intensive Care Medicine Body Mass Index Pulmonary function testing Insulin resistance Risk Factors Internal medicine medicine Humans Obesity Asthma business.industry digestive oral and skin physiology Case-control study Middle Aged Obestatin medicine.disease Ghrelin respiratory tract diseases Endocrinology Case-Control Studies Female Surgery Insulin Resistance business Body mass index Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | Tuberk Toraks. 68:9-16 |
| ISSN: | 0494-1373 |
| Popis: | Introduction This study aimed to evaluate serum levels of ghrelin and obestatin as well as the ghrelin/obestatin ratio in non-obese patients with asthma and in healthy non-asthmatic controls and analyzed the relationships to clinical outcomes. Materials and methods 51 patients with stable persistent asthma and 36 healthy controls were included to the study. Pulmonary function tests were conducted in all case. Skin prick test and an asthma control test were conducted in patients with asthma. All patients and controls were compared in terms of ghrelin and obestatin levels, as well as the ghrelin/obestatin ratio. Plasma concentrations of ghrelin and obestatin were detected by enzymelinked immunosorbent assay. Homeostasis model assessment-insulin resistance (HOMA-IR) scores were calculated as an index of insulin resistance. Result No differences in ghrelin or obestatin levels or the ghrelin/obestatin ratio were detected between patients with asthma and the control group. Ghrelin levels were significantly lower in obese patients. The HOMA-IR score was significantly higher in patients with asthma than in controls. Conclusions Ghrelin and obestatin levels, and the ghrelin/obestatin ratio, were similar in controls and patients with stable asthma. Although the groups were similar in terms of body mass index and waist circumference, the HOMA-IR score was significantly higher in patients with asthma. |
| Databáze: | OpenAIRE |
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