Enhanced in vivo cytotoxicity of recombinant human tumor necrosis factor with etoposide in human renal cell carcinoma
| Autor: | Thomas E. Keane, Susan Poulton, Jonathan T. Donaldson, Philip J. Walther |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Necrosis
Urology Athymic mouse Mice Nude Mice Therapeutic index In vivo medicine Animals Humans Carcinoma Renal Cell Etoposide Tumor Necrosis Factor-alpha business.industry Combined Modality Therapy Kidney Neoplasms Recombinant Proteins Toxicity Cancer research Subrenal Capsule Assay Tumor necrosis factor alpha Immunotherapy medicine.symptom business medicine.drug |
| Zdroj: | Urological Research. 18:245-250 |
| ISSN: | 1434-0879 0300-5623 |
| Popis: | The combination of tumor necrosis factor (TNF) and etoposide (ETP) was evaluated for potential cytotoxic efficacy against a human renal cell carcinoma xenograft using an in vivo assay employing an athymic mouse host with tumor implanted a the subrenal capsule site. Both antitumor efficacy (relative survival or RTS) and toxicity (weight loss) of TNF and ETP alone and in combination were evaluated. While TNF and ETP alone were mildly inhibitory (RTS 90% and 71%, respectively), the combination caused marked tumor inhibition (45% of controls). Host toxicity encountered with the combination did not exceed the toxicity associated with ETP alone, suggesting that the therapeutic index may have been augmented. It is concluded that enhanced antitumor activity without substantial augmentation of toxicity is observed with this combination, providing a rationale for further evaluation of tumor necrosis factor-based regimens for the treatment of advanced renal carcinoma. |
| Databáze: | OpenAIRE |
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