Intravenous contrast-enhanced cone beam computed tomography (IVCBCT) of intrahepatic tumors and vessels
| Autor: | Cynthia L. Eccles, Maria A. Hawkins, Douglas Moseley, Laura A. Dawson, Mark T Lee, Regina V. Tse |
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| Rok vydání: | 2016 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
medicine.medical_specialty Cone beam computed tomography lcsh:R895-920 medicine.medical_treatment SABR volatility model urologic and male genital diseases lcsh:RC254-282 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine stomatognathic system Ct number medicine Image acquisition Radiology Nuclear Medicine and imaging Scientific Article Intravenous contrast business.industry respiratory system lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease equipment and supplies Radiation therapy Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Radiology Liver cancer business |
| Zdroj: | Advances in Radiation Oncology Advances in Radiation Oncology, Vol 1, Iss 1, Pp 43-50 (2016) |
| ISSN: | 2452-1094 |
| DOI: | 10.1016/j.adro.2016.01.001 |
| Popis: | Purpose Liver tumors are challenging to visualize on cone beam computed tomography (CBCT) without intravenous (IV) contrast. Image guidance for liver cancer stereotactic body ablative radiation therapy (SABR) could be improved with the direct visualization of hepatic tumors and vasculature. This study investigated the feasibility of the use of IV contrast-enhanced CBCT (IV-CBCT) as a means to improve liver target visualization. Methods and Materials Patients on a liver SABR protocol underwent IV-CBCT before 1 or more treatment fractions in addition to a noncontrast CBCT. Image acquisition was initiated 0 to 30 seconds following injection and acquired over 60 to 120 seconds. “Stop and go” exhale breath-hold CBCT scans were used whenever feasible. Changes in mean CT number in regions of interest within visible vasculature, tumor, and adjacent liver were quantified between CBCT and IV-CBCT. Results Twelve pairs of contrast and noncontrast CBCTs were obtained in 7 patients. Intravenous-CBCT improved hepatic tumor visibility in breath-hold scans only for 3 patients (2 metastases, 1 hepatocellular carcinoma). Visible tumors ranged in volume from 124 to 564 mL. Small tumors in free-breathing patients did not show enhancement on IVCBT. Conclusions Intravenous-CBCT may enhance the visibility of hepatic vessels and tumor in CBCT scans obtained during breath hold. Optimization of IV contrast timing and reduction of artifacts to improve tumor visualization warrant further investigation. |
| Databáze: | OpenAIRE |
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